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the staphylococcus aureus rnome and its commitment to virulence金黄色葡萄球菌rnome及其毒性的承诺
Review
The Staphylococcus aureus RNome and Its Commitment
to Virulence
1 2 3 4
Brice Felden *, Franc¸ois Vandenesch , Philippe Bouloc , Pascale Romby
´ ´ ´ ´
1 Universite de Rennes, Inserm U835, UPRES EA2311, Biochimie Pharmaceutique, Rennes, France, 2 Inserm U851, Universite de Lyon, Centre National de Reference des
´ ´ ´ ´ ´
Staphylocoques, Lyon, France, 3 Laboratoire Signalisation et Reseaux de Regulations Bacteriens, Institut de Genetique et Microbiologie, CNRS, UMR 8621, IFR115, Centre
´ ´ ´ ´
Scientifique d’Orsay, Universite Paris Sud 11, Orsay, France, 4 Architecture et Reactivite de l’ARN, Universite de Strasbourg, CNRS, IBMC, Strasbourg, France
RNA, called RNAIII, is a paradigm for RNA-mediated regulation
Abstract: Staphylococcus aureus is a major human of virulence genes [12,13]. It is the effector of the accessory gene
pathogen causing a wide spectrum of nosocomial and regulator (agr) system [4], which controls the switch between the
community-associated infections with high morbidity and expression of surface proteins and excreted toxins. Within the last
mortality. S. aureus generates a large number of virulence few years, several reports highlighted the importance and diversity
factors whose timing and expression leve
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