高氟对甲状腺功能和认知能力影响.pdfVIP

Abstract Objective: To Stud y the impact on brain after the high fluorine caused to thyroid damage. Observes the high fluorine harm thyroid gland specifically, after causes the thyroid function to reduce lowly, the thyroid function reduces lowly whether together constitutes the factor with the high fluorine which the brain harms. Thus further verifies the pathogenesis which the high fluorine result brain harms, for carries out fluorosis preventing and controlling to provide the theory basis effectively. Methods: 18 Wistar rats were randomly divided into six each of the normal group (group A), high fluoride hypothyroidism group (group B), high fluoride hypothyroidism alternative group (group C). A group drinking tap water, group B, group C drink containing NaF 100mg / l of high-fluorine water, seven months after the re-group C 0.04% thyroid tablets by 1.8 ml / kg / d gavage replace three weeks. RIA method for determination of serum TT3, TT4, TSH; HE staining of thyroid and hippocampal morphology; immunohistochemical staining technique hippocampal CA1 CA3 region of the Group NMDAR2B glutamate receptor subunit expression changes. Results: 1. Serum TT3, TT4, TSH change: The high fluorine hypothyroidism group (B group) TT3, TT4 are lower than the normal group obviously (P 0.01), but TSH presents is higher than tendency of the normal group. high fluoride hypothyroidism alternative group (group C) TT3, TT4 and TSH and normal control group close (P all 0.05). 2.HE staining microscopy (1) changes in the thyroid: Group A rats normal follicular epithelial structure, arranged in an orderly manner, without filter cell hyperplasia or contraction. Grou