选择性COX-2抑制剂塞来昔布对人子宫内膜癌细胞增殖及凋亡的影响.pdf

／一…一……。…。一、 { 英文论著摘要 } 、一～一～…一…一．， Effectsof human endometrial celecoxibOil uterus carcinoma and cell proliferationapoptosis Background Endometrial cancerisoneofthemost prevalent caIleer，ac— gynaecological forabout20—30％ofall ofthefemale tract．The counting malignancy genital incidenceofendometrialcancerincreasedintherecent beclose years，already orevenexceed to thatofcervicalcarcinoma．The diseaseincluded precancerous endometrial hyperplasia． ． the inthe of Cyclooxygenase(COX)iskeyenzymebiosynthesisprostaglan— din．COX一2istheinducibleformof ofCOX一 cyclooxygenase．Theexpression 2is invarioustumortissuesandcell indi— up—regulated lines．Multiplerepots caredthatCOX一2was related tumor closely tothe and to the radiochemical sion，metastasis，prognosissensitivity therapy． Anumberof studieshavefoundassociationsbetween epidemiological long tern]non—steroidal andalowerinci— anti—inflammatorydrugs(NSAIDs)use denceand fromcancersofthe mortality bladderand ofselectiveCOX一2inhibitors prostate，urinaryovary．Theusage in