LPS诱导动物胆汁淤积模型制备及微管蛋白对BSEP功能的影响的研究.pdf

童望盔兰堡±翌塞生兰些丝塞 LPS-Induced altersthe Experimental Cholestasis：paclitaxel and ofbilesalt pump expressiontrafficking export ● i Abstract j aimofthis isto the objective：The study investigaterelationship betweenbilesalt cholestasis theThe exportpump(BSEP)andbystudying cholestasis microtubule’S LPS-induced models，and experimental explore in effortstoBSEP the and ofBSEP trafficking byoverviewingexpression sectionsofrats with injectedpaclitaxel． Methods：The LPS—inducedcholestasismodelswere experimental as with orvehicleacontr01．Models paclitaxel injectedintraperitoneally were to9at the of is5．Tofmd random,and everygroup grouped samples the of examinedthe ofalkaline cholestasis，we activity development andbileacids．Sections levelsoftotalbilimbin phosphatase(ALPase)，the were aco