C反应蛋白及高血压病心房颤动关系临床探究.docVIP

C反应蛋白及高血压病心房颤动关系临床探究 　 作者：姜卫东,陈菊，高想,倪卫兵,陶志强 【摘要】 目的：探讨C反应蛋白作为系统炎症因子在高血压病心房颤动的发生和发展中的作用。方法：对资料完整的87例高血压病患者，高血压对照组29例，阵发性房颤组26例和永久性房颤组32例，测定并比较各组C反应蛋白水平。结果：血清C反应蛋白水平：心房颤动组比正常对照组的水平明显增高（Plt;0.01），永久性房颤组高于阵发性房颤组（Plt;0.01）。左房直径与C反应蛋白水平呈正相关（r=0.56，Plt;0.05）。结论：C反应蛋白在心房颤动患者中明显升高，说明炎症状态在高血压病心房颤动的发生和维持中起一定作用。 【关键词】 心房颤动；高血压；C反应蛋白 　　Correlation between atrial fibrillation of hypertension and C-reactin protein 　　Abstract：Objective:To study the correlation between atrial fibrillation of hypertension and C-reactin protein.Methods:A total of 87 patients with hypertension were divided to paroxysmal atrial fibrillation group(26 cases),persistence atrial fibrillation group(32 cases),and control group(29 cases).All subjects were detected serum C-reactin protein concentration and left atrial internal diameter by echocardiogram.Results:The level of serum C-reactin protein was (3.68±1.63) mg/dl in paroxysmal atrial fibrillation group,(5.62±1.68) mg/dl in persistence atrial fibrillation group,whose were higher than that in hypertension control group［(1.14±0.52) mg/dl,Plt;0.01］.The level of serum C-reactin protein of persistence atrial fibrillation group was more than that in persistence atrial fibrillation group(Plt;0.01).The level of serum C-reactin protein was positively related with left atrial internal diameter（r=0.56，Plt;0.05）.Conclusion:The level of serum C-reactin protein significantly increase in patients with atrial fibriliation,it suggest that inflammation may possess certain effect in genesis and development of atrial fibrillation followed hypertension. Author′s　address：Department of Cardiology,Traditional Chinese Medicine Hospital of Nantong,Nantong,Jiangsu,226001,China 　　Key words：Atrial fibrillation;Hypertension;C-reactin protein 　　近年研究发现，C反应蛋白(CRP)不仅是全身炎症和冠心病的危险因素的标记物，而且可以预测心房颤动的发生和持续。本研究入选87例高血压病患者，以探讨C反应蛋白在高血压病心房颤动中的作用和意义。 　　1 资料与方法 　　1.1 一般资料 选择2003年10月至2006年10月入住我院心内科，资料完整的高血压病患者87例，男52例、女35例，年龄47～82，平均（62.3士14.2)岁；高血压病诊断符合2004年《中国高血压治疗指南》的诊断标准。所有患者均经病史、体格检查、心电图或2