乳腺癌激素受体 CerbB2 P53 nm23基因表达及及临床病理特征关.docVIP

乳腺癌激素受体 CerbB2 P53 nm23基因表达及及临床病理特征关 　 作者：胡江辉，赵文健，谢开红，刘保安 【摘要】 目的：探讨雌激素受体（ER）、孕激素受体（PR）及CerbB2、P53、nm23基因在乳腺癌组织中的表达及其与临床病理特征之间的关系。方法：用免疫组织化学S-P法检测113例乳腺癌组织中ER、PR及CerbB2、P53、nm23的表达。并结合乳腺癌临床病理特征进行分析。结果：113例乳腺癌组织中ER、PR及CerbB2、P53、nm23阳性表达率分别为49.6%、39.8%、59.3%、40.7%和71.7%，与临床分期、肿瘤大小、病理类型、年龄无关（P＞0.05）；CerbB2、P53阳性表达率与腋淋巴结转移呈正相关(P＜0.05）。nm23阳性表达率与腋淋巴结转移呈负相关（P＜0.05）。ER和（或）PR、nm23阳性组乳腺癌复发率低于阴性组(P＜0.05）。CerbB2、p53阳性组乳腺癌复发率高于阴性组（P＜0.05）。CerbB2的表达在ER、PR阴性组高于阳性组（P＜0.05）。结论：联合检测ER、PR与CerbB2、P53、nm23表达对判断乳腺癌的预后、指导临床治疗具有十分重要的意义。 【关键词】 乳腺癌；雌激素受体；孕激素受体；CerbB2；P53；nm23；基因 　 Abstract： Objective To explore expressions of ER，PR，CerbB2,P53,nm23 in breast carcinoma and their relationships with clinicopathology. Methods The expression of ER，PR，CerbB2,P53 and nm23 was detected by SP immunohistochemical method in 113 cases of breast carcinoma,and their relationship with clinicopathology was analysed. Results Positive expression rates of ER,PR, CerbB2,P53 and nm23 were 49.6%、39.8%、59.3%、40.7% and 71.7% respectively.There was no correlation between the positive expressions of ER、PR、CerbB2,P53 and nm23 with clinical staging，tumor diameter，histological types and patient age（P＞0.05）．The expressions of CerbB2 and P53 were correlated positively with lymph node metastasis（P＜0.05）.The expression of nm23 was correlated negatively with lymph node metastasis（P＜0.05）.The recurrence rates of the carcinomas with positive expression of ER/PR and nm23 were lower than those with negative expression（P＜0.05）.On the contrary,the relapse rates of the carcinomas with positive expression of CerbB2 and P53 were superior to those with negative expression(P＜0.05）. The positive expression rate of CerbB2 was higher in the group with positive expression of ER and PR than negative group(P＜0.05). Conclution Combined detection of the expression of ER,PR, CerbB2,P53 and nm23 in breast carcinoma tissue play a important role in judging prognosis and guiding clinical treatment. Key words: B