可明胶囊联合沃丽汀片治疗中心性浆液性视网膜脉络膜病变临床观.docVIP

可明胶囊联合沃丽汀片治疗中心性浆液性视网膜脉络膜病变临床观 　 作者：吴仁毅 崔清风 杨芳 徐雯 陈芝清 苏兆安 【摘要】 目的 观察可明胶囊治疗中心性浆液性脉络膜视网膜病变(central serous chorio- retinopaty, CSC) 的临床疗效。方法 选择门诊随访资料完整的CSC患者67例（75眼），分为常规治疗（口服沃丽汀片）和联合治疗（口服沃丽汀片和可明胶囊）。在药物治疗前及治疗后4、8周进行光学相干断层扫描和眼底血管荧光造影分析。结果 治疗后8周复查两组治疗有效率分别为87%和96%，联合治疗效果显著优于单用沃丽汀；两组患者治疗期间均无明显药物相关不良事件。结论 与单用沃丽汀口服治疗相比，可明胶囊联合沃丽汀治疗CSC能显著提高疗效，且治疗安全。 【关键词】 可明胶囊 中心性浆液性视网膜脉络膜病变 光学相干断层扫描 血管荧光造影 【Abstract】 Objective To evaluate the therapeutic effect of Kemin capsule and iodized lecithin tablet combination in the treatment of central serous chorio-retinopathy (CSC). Methods 67 patients (75 eyes) of CSC were enrolled and were divided into two groups with one group received conventional therapy (iodized lecithin tablet only) and the other received combined therapy (Kemin capsule and iodized lecithin tablet). Before medication, 4 and 8 weeks after medication, Optical coherence tomography and fluorescein angiography, as well as routine ocular examinations were performed on the eyes treated. Result At the end of 8 weeks after medication, the effective rate in the combined therapy group was 96%, which was significantly higher than that of the conventional therapy group (87%). No obvious drug-related adverse event was noticed in both two groups during the period of treatment. Conclusions Compared to mono-therapy iodized lecithin tablet, combination therapy of Kemin capsule and iodized lecithin tablet increases the effective rate without increase the side effect. 【Key words】 Kemin Capsule Central Serous Chorio-retinopathy Optical Coherence Tomography Fluorescein Angiography 中心性浆液性脉络膜视网膜病变（central serous chorio-retinopathy，CSC）简称“中浆”，为眼科的常见病之一，多发生于20～50岁青壮年男性，极少＞60岁。此病男女之比约10∶1，属中医范畴的“视瞻有色”。CSC虽是一种自限性疾病，但易复发，复发率一般在l8.5％左右［１］，可造成严重视力损害，给患者带来极大痛苦。作者2008年5至11月采用可明胶囊治疗CSC，取得满意疗效，报道如下。 1 临床资料 1.1 一般资料 选择本院眼科门诊就诊随访资料完整的67例(75眼)CSC患者。随机单盲分组，进行常规治疗（口服沃丽汀片）或联合治疗（可明胶囊口服联合沃丽汀片口服）。患者入选标准：(1)经眼底血管荧光造影（fluorescein angiography, FFA）确诊为中浆；(2)裂隙灯显微镜和直接检眼镜检查表明屈光间质透明；(3)排除青光眼、葡萄膜炎、眼外伤等眼部疾病及病史；(4)无糖尿病、高血压