普贝生用于促宫颈成熟临床观察.docVIP

普贝生用于促宫颈成熟临床观察 　 作者：邵惠芬 方根娟 李茂宇 沈旭霞 【摘要】 目的 观察普贝生促宫颈成熟的有效性和安全性。 方法 将120例妊娠足月、宫颈Bishop评分≤5分、无阴道分娩禁忌证、单胎头位孕妇随机分为两组。63例以阴道放置普贝生促宫颈成熟为研究组，57例用小剂量催产素促宫颈成熟为对照组。比较两组孕妇的宫颈Bishop评分、用药至临产时间、总产程、阴道分娩率及对胎儿、新生儿的影响。结果 用药12h后研究组促宫颈成熟48例显效，56例有效,而对照组18例显效，28例有效，两组比较差异有极显著性(P＜0.001)。研究组从用药至临产时间为（7.18±8.12）h，而对照组为（22.75±7.93）h，两组比较差异有极显著性(P＜0.001)。研究组的阴道分娩率为80.95%，而对照组为36.84%，两组比较差异有极显著性(P＜0.001)。两组间胎儿窘迫的发生率、产后出血量及新生儿出生时状况差异无显著性（P＞0.05）。 结论 普贝生可安全、有效地用于足月促宫颈成熟。 【关键词】 普贝生 催产素 促宫颈成熟 　　【Abstract】 Objective To investigate the efficacy and safety intravaginal E2(PGE2)proess for cervical ripening. Methods One hundred and twenty pregnant women who had entry Bishop score of 5 or less ,carrying singleton pregnancies in cephalic presentation with a gestational age of at least 37 weeks were divided into two groups. Experimental group(63 cases)received a propess inserted into vaginal for cerval ripening ,while control group(57 cases) received intravenous drip of low does oxytocin.The cervical Bishop score ,the time of labor starting , the time of labor ,vaginal delivery rate,fetal and neonatal condition were compared between the two groups. Results Twelve hours after administration , It was excellence in 48 cases, effective in 56 cases in the experimental group and for control group, excellence in 18 cases, effective in 28 cases .There was singnificant difference between two groups(P＜0.001). The mean time to labor starting in experimental group(7.18±8.12h) was significantly shorter than in control group (22.75±7.93h) (P＜0.001）. The rate of vaginal delivery in experimental group was 80.95% and in control group was 36.84% ,the difference was also significant(P＜0.001).No significant differences were found in fetal distress,neonatal Apgar scores or postpartum hemorrhage between the two groups（P＞0.05）. Conclusion Propess is effective and safe in producing cervical ripening. 　　【Key word】 Propess Oxytoin Cervical ripening 妊娠晚期宫颈成熟是决定能否成功阴道分娩的重要因数。对宫颈条件不成熟的孕妇需要促宫颈成熟；催产素是公认安全有效并早已用于临床的药物。普贝生是1994年获美国FD