1.93 图表 Age-Related Comparisons of Evolution of the Inflammatory.pdf

Transl. Stroke Res. (2012) 3 (Suppl 1):S132–S146 DOI 10.1007/s12975-012-0151-3 ORIGINAL ARTICLE Age-Related Comparisons of Evolution of the Inflammatory Response After Intracerebral Hemorrhage in Rats Starlee Lively Lyanne C. Schlichter Received: 9 February 2012 /Revised: 28 February 2012 /Accepted: 1 March 2012 /Published online: 16 March 2012 # The Author(s) 2012. This article is published with open access at S Abstract In the hours to days after intracerebral hemor- animals, the up-regulation of 26 in 27 genes (not IL-4) rhage (ICH), there is an inflammatory response within the was detected within the first week. Differences in timing brain characterized by the infiltration of peripheral neutro- or levels between young and aged animals were detected for phils and macrophages and the activation of brain-resident 18 of 27 genes examined (TLR2, GFAP, IL-1β, IL-1ra, IL- microglia and astrocytes. Despite the strong correlation of 1r2, iNOS, IL-6, TGFβ, MMP9, MMP12, IL-13, IL-4Rα, aging and ICH incidence, and increasing information about IL-13Rα1, IL-13Rα2, MRC1, ARG1, CD163, CCL22), cellular responses, little is known about the temporal- and with a generally less pronounced or delayed inflammatory age-related molecular responses of the brain after ICH. response in the aged animals. Importantly, within this com- Here, we monitored a panel of 27 genes at 6 h and 1, 3, plex response to experimental ICH, the induction of pro- and 7 days after ICH was induced by injecting collagenase inflammatory, potentially harmful mediators often coincided into the striatum of young adult and aged rats. Several with resolving and beneficial molecules. molecules (CR3, TLR2, TLR4, IL-1 β, TNFα, iNOS, IL-6) were selected to reflect the classica