钆喷酸（GD DTPA）.doc

钆喷酸（GD DTPA） GD DTPA GD DTPA, Gd DTPA, Gd DTPA It is up to 0531 [English name] Gadopentetate Dimeglumine [x] x ray contrast agent [alias] gadolinium DTPA, Magnevist [foreign names] Gadopentetate, Dimeglumine, Magnevist [pharmacological action] Gd3 has 7 unpaired electrons, a strong magnetic paramagnetic metal ions, T1 and T2 can significantly shorten the relaxation time, especially in T1 was more obvious in the concentration range of 0 ~ 1mmol / L relaxation time in a linear decline, thus affecting the signal strength of MRI. [pharmacokinetics] this product is a chelate of meglumine, which is related to meglumine in vivo. After intravenous administration, the fluid is rapidly dispersed into the extracellular fluid of the tissues of the body, and then filtered out by the glomerular filtration. A small amount is excreted in the gastrointestinal tract and excreted with fecal matter. This product can enter the diseased tissue through the damaged blood brain barrier. [indications] enhancement of magnetic resonance imaging (MRI) includes enhanced examination of the nervous system, myocardium, liver, breast, bone, kidney and other organs and tissues. [usage] intravenous injection, 0.lmmol / kg. 5min enhanced imaging after injection, and the increase effect can be maintained by 45min. [adverse reactions] the adverse reactions of this product were significantly lower than that of iodine contrast agents. There is a slight headache (8.7%), followed by cold injection site (4.8%, nausea and vomiting, numbness, dizziness (2%); otherwise, the injection site burning local edema, fatigue, chest tightness, local lymph node inflammation, hypotension, abdominal pain, chest pain, anxiety, convulsions, salivation, itching of the throat, cough, skin rash, dry mouth, abnormal taste, sweat, tears, the incidence rate of less than 1%. [Specification] injection: 20ml (0.5mol / L). Generic name: Dimeglumine Gadopentetic Acid Injection Dimeglumine Gadopentetic Acid Injection: English