盐酸氟桂利嗪胶囊（Flunarizine Hydrochloride Capsules）.doc

盐酸氟桂利嗪胶囊（Flunarizine Hydrochloride Capsules） Brand name: Flunarizine Hydrochloride Capsules Flunarizine Hydrochloride Capsules manual] Generic name: Flunarizine Hydrochloride Capsules English Name: FlunarizineHydrochlorideCapsules Main ingredients: This product is the main ingredients: flunarizine hydrochloride. Its chemical name is: (E) -1-[bis (4- fluoro phenyl) methyl]-4-2 (2- propylene group -3- phenyl) - piperazine two hydrochloride. Molecular formula: C26H26F2N2. 2HCl Molecular weight: 477.42 Properties: This product is capsule. Pharmacological action: This product is a calcium channel blocker. It can prevent the damage caused by ischemia and other pathological intracellular calcium overload. This product has: to alleviate vasospasm, vasoconstrictor persistent spasm caused a long-lasting inhibition, especially on the basilar artery and internal carotid artery significantly, the ratio of cinnarizine is 15 times stronger; inhibition of the vestibular cochlear arteriole, can increase blood flow, improve the circulation of the vestibular organ; epilepsy this product, can block the pathological calcium overload of nerve cells and prevent paroxysmal depolarization, cell discharge, so as to avoid the seizure; the protection of myocardium, significantly reduce myocardial ischemic injury; the effect of flunarizine is renal function, can be used for chronic renal failure; in addition the products and antihistamine effects. Pharmacokinetics: the product reached the peak value of plasma 2~4 hours after oral administration, and the T1/2 ranged from 2.4 to 5.5 hours, mainly in the liver, lung, pancreas, and stored in the bone marrow and fat. Even for 5~6 weeks, the steady-state blood concentration, 90% and plasma protein binding, can pass through the blood-brain barrier, and can be secreted with milk. Most of them are metabolized by the liver and excreted by the digestive tract. Bile enters the intestines and is excreted through the stool. Indications / efficacy: (1) cerebr