植物聚戊烯醇的理化特性和药理活性研究进展.pdf

第43卷第2期 生摇 物摇 质摇 化摇 学摇 工摇 程 Vol.43 No.2 2009年3月 Biomass Chemical Engineering Mar. 2009 蕰藭蕰蕰蕰蕰蕰蕰蕰藭蕰蕰 综述评论 藭蕰蕰蕰蕰蕰蕰蕰蕰 藭 植物聚戊烯醇的理化特性和药理活性研究进展 王成章,叶建中,陈西娟,陈虹霞,杨 兰 (中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室; 国家林业局林产化学工程重点开放性实验室, 江苏 南京 210042) 摘摇 要:植物聚戊烯醇是一类异戊烯基结构聚合体的类脂化合物,与人体内多萜醇具有相似的结构特征和生理活性,而 多萜醇是糖基与蛋白质生物合成的关键载体。 本文重点介绍植物聚戊烯醇的结构类型、HPLC分析、结构鉴定方法和光 谱特征、药理和临床应用。 针对我国银杏叶加工存在的问题,提出要重点研究银杏叶聚戊烯醇新的有效活性成分,促进 银杏叶聚戊烯醇作为保健品和药物的开发。 关键词:植物聚戊烯醇;理化特性;药理活性;药物开发 中图分类号:TQ91摇 摇 摇 摇 摇 摇 摇 文献标识码:A摇 摇 摇 摇 摇 摇 摇 文章编号:1673-5854(2009)02-0037-06 Research Progress of Physicochemical Properties and Pharmacological Activities of Plant Polyprenols WANG Cheng鄄zhang,YE Jian鄄zhong,CHEN Xi鄄juan,CHEN Hong鄄xia,YANG Lan (Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization;Key and Open Lab.on Forest Chemical Engineering,SFA,Nanjing210042,China) Abstract:Plant polyprenols,whichhavesimilarstructureandbiologicalactivitytodolicholsinhumanbody,arelipidsofpolymer with isoprenyl units. However, dolichols are key carriers in biosynthesis process of glycosyl derivatives with protein. The structure types,HPLC analysis,structural identification,spectral characteristics,pharmacology and clinical application of plant polyprenolswere mainly introduced in this paper. According to present problems in processing of Ginkgo biloba L. leaves in China,it is suggestedto mainly study thenew bioactive componentsof polyprenolsin G. biloba L. andpromotethe development of plant polyprenolsfrom G. biloba L. as health care products and drug. Key words:plant polyprenols;physicochemical properties;pharmacological activities;drug development 摇 摇 多萜醇(dolichol)广泛存在于人体和哺乳动 的不足,能促进机体的造血功能。 由于体内多萜 物的肝、脾、肾、胰、甲状腺