乙酰氯（Acetyl chloride）.docVIP

乙酰氯（Acetyl chloride） Background technology of acetyl chloride Acetyl chloride is an important intermediate in organic synthesis and acetylation reagent, acetic anhydride acylating ability than the strong, widely used in organic synthesis, can be used in the production of pesticide, medicine, new complexant, and many other fine organic synthesis intermediates in medicine, which can be used for preparing 4- 2, two chloro -5- (fluoroacetophenone ciprofloxacin intermediate) and Bloven. Acetyl chloride is also a catalyst for chlorination of carboxylic acids. The main industrial method of acetyl chloride is acetic acid with phosphorus trichloride. Under normal pressure, heating slowly add excess phosphorus trichloride acetic acid, distillation, 98% acetyl chloride, and hydrochloric acid by-product phosphite. The reaction mechanism is complex and the side effects are more. The main reaction: the main side reaction of PCl3 + 3CH3COOH, H3PO3 + 3CH3COCl: CH3COCl + CH3COOH - (CH3CO) O2 + HCl PCl3 + CH3COOH, CH3COOPCl2 + HCl CH3COCl + H3PO3, 2OCOCH3 + P (OH) HCl 2P (OH) 2OCOCH3 CH3C (PO3H2) 2OCOCH3 the above method has the following defects: 1, due to the production process and put the excess phosphorus trichloride and process, the reaction itself is complex, the impurities in refined acetyl chloride. 2, the finished acetyl chloride contains a small amount of phosphorus impurities, stored for a long time volatile. 3, the by-product phosphite contains certain hydroxyl ethyl two phosphonic acid acetate, the appearance is not good, affected the application of the by-product phosphite acid, and the economic benefit is poor. 4, the 98% acetyl chloride purification process to 99%, resulting in residue in the kettle, residue can not be recycled, resulting in the three wastes. 5, raw material consumption is too high, and the theoretical yield a distance; industrial investment 830kg acetic acid, 830kg 1000kg98% acetyl chloride, phosphorus trichloride, 440kg phosphate and a small amount