局灶性脑损害患者视觉注意环路的小世界网络属性分析.PDF

·临床研究· 局灶性脑损害患者视觉注意环路的 小世界网络属性分析* 徐光青 兰 月 蔡华崧 陈正宏 裴 中 黄东锋1 2 3 1 4 1 摘要 目的：探讨局灶性脑损害患者视觉注意网络的连通性及其小世界特征。 方法：对2 例局灶性后顶叶损害、2 例背外侧前额叶损害、2 例颞叶损害（其中1例为手术前后）和1例锥体束损害患者 进行静息态fMRI 检测，然后进行功能网络建立和小世界属性分析。 结果：所有局灶性脑损害患者的脑功能网络在给定阈值范围（0.05—0.5）内都具有小世界属性。局灶性后顶叶、背外 侧前额叶、颞叶和锥体束损害患者之间，Gamma 系数差异（P0.05 ）和Sigma 系数差异（P0.01 ）均具有显著性意义。 结论：小世界网络分析为视觉注意网络的连通性研究提供了一个非常有价值的方法。我们推测，小世界网络检测方 法应该可以作为局灶性脑损害神经功能损害的影像学生物标记。 关键词 视觉注意；脑损害；功能性核磁共振；小世界网络 中图分类号：R651 文献标识码：A 文章编号：1001-1242（2013 ） Small-world network analysis of visual attentional connectivity in patients with local brain lesions/XU Guangqing, LAN Yue, CAI Huasong,et al.//Chinese Journal of Rehabilitation Medicine,2013,28(): Abstract Objective: This study demonstrates a disruption of the functional organization of the visual attention network in patients with local brain lesions. Method: We employ a resting state functional MRI (fMRI) to examine changes of the functional connectivity in patients with local brain lesions, including 2 parietals, 2 frontals, 2 temporals and 1 internal capsule damag- er. And then, small-world metrics (characteristic clustering coefficient and path length) were computed using graph analytical methods. Result: In the frequency interval 0.05 to 0.5 Hz, functional brain networks in all subjects showed small-world organization of brain activity. However, there were significant differences in the small-world properties of clus- tering coefficients among these patients (P0.05). Clustering coefficients for the visual attention networks were significantly lower, indicative of disrupted local connectivity. Conclusion: These results suggest that small-world metrics can characterize the functional organization of the visual attention network in local brain lesions. Moreover, our findings further su