五指山小型猪近交系培育与遗传资源创新inbreedinglinecultureof.pdfVIP

Online system: http://www.j 业 生 物 技 术 学 报 Journal of Agricultural Biotechnology 2012, 20(8): 849~857 DOI: 10.3969/j .issn.1674-7968.2012.08.001 专家论坛 Expert Forum 五指山小型猪近交系培育与遗传资源创新 * 冯书堂 李奎 牟玉莲 杨述林 中国农业科学院北京畜牧兽医研究所，农业部畜禽遗传资源与种质创新重点实验室 ， * 通讯作者 fst508@ 要 中国农业科学院北京畜牧兽医研究所二十多年来，利用2 头五指山小型猪 (Sus scrofa ) (Wuzhishan mini-pig,WZSP)，采用近交繁育，培育 近交系，最高已获得近交F22 ，并进行开发应用。对 WZSP 近交系全 因组测序并与人(Homo sap iens) 、短尾猴(Macaque mulatta)和大鼠(R attus norvegicus) 比 对，初步分析发现，该近交系全 因组具有较高的纯合度和特异的分子遗传特征，不仅证明了我国实现遗 ，而且证明该近交系猪是人类理想的 替难者 。 传资源创新培育近交系的可靠性 “ ” 实现我国小型猪遗传资 ， 。 源创新的培育目标 取得了一定的经济和较大社会效益，有着重要的现实和历史意义 关键词 五指山小型猪，近交系，全 因组，遗传资源 Inbreeding Line Culture of Wuzhishan Mini-pig and the Innovation in Nurturing Inbred for Chinese Genetic Resources FENG Shu-Tang* LI Kui MU Yu-Lian YANG Shu-Lin Institute of Animal Science, Chinese Academy of Agricultural Sciences. Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation, Ministry of Agriculture, Beij ing 100 193, China * Corresponding author, fst508@ Abstract Experimental animals are important research content of the research conditions. In past more than 20 years, the Wuzhishan mini-pig (Sus scrofa )(WZSP) inbred line has been carried out by Institute of Animal Science, Chinese Academy of Agricultural Sciences, with inbreeding heddle measure. Up to now, inbreeding F22 of pigs herd have been already obtained which has been applied on human medicine industry. Recently, the whole-genomesequencing of the inbreds WZSP was performed which would be inbred for medical experiments. Compared with human(Ho