细胞凋亡蛋白酶活化因子Apafs的功能研究.pdfVIP

11 　5 Vol.11, No.5 1999 10 Chinese Bulletin of Life Sciences Oct., 1999 (Apafs) 朱国萍　徐　冲 (　　230026) 　　 (Apafs) (PCD) (caspase Casp)。Apaf-1、 c (Apaf-2)Casp-9 (Apaf-3), Casp-9 Casp-3, PCD 。Apafs 。Apafs 。 　, , , 　Q25　Q556.3　Q556.9 Functions of apoptosis protease activating factors HU Guo-Ping 　　XU Chong (Department of Molecular Biology and Cell Biology, School of Life, University of Science and Technology, Hefei 230026) Abstract　Apoptosis protease activating factors (Apafs)participate the activation of Asp-specific cys- teine protease (caspase or Casp)in programmed cell death (PCD).Apaf-1, cytochrome c and Casp-9 first form an apoptosome.Then Casp-9 activates Casp-3 which may trigger the cytological events in the terminal stage of PCD.Mutations or deletions of Apafs can result in the abnormal development of brain and retina.Investigation of the functions of Apafs may provide a new pathway for the therapy of neurodegenerative diseases and cancer. Key words　apoptosis protease activating factors, caspase, development, apoptosis 　　 (apoptosis) ;C-12 WD-40 ; 2+ [3] (programmed cell death, PCD), P-loop Mg 。, CED-4 。 CED-9 CED-3 , PCD (caspase Casp)。 CED-9/4/3 。Apaf-1 CED-4, 12 caspase Bcl-2 Bcl-X Casp-9 。Casp-9、 L 。caspase Bcl-XL Apaf-1 [ 1] [4] 。 (apoptosis 。Apaf-1 protease activating factors, Apafs)Apaf-1、 (prodomain ) CARD caspase , c (Cyt c/Apaf-2)Casp-9 (Apaf-3) Casp-1、 Casp-2、 Casp-8 Casp-9, Apaf-1 [2]