氧化型染发剂对小鼠的亚慢性毒性研究.pdfVIP

氧化型染发剂对小鼠的亚慢性毒性研究 onSubchronicofOxidizedHair toMice Study Toxicity Dyes 袁营，浦跃朴，尹立红 (东南大学公共卫生学院劳动卫生与环境卫生学系，南京210009) YUANHui,PU Pubhc Yue-pu,YINLi-hong(Schoolof Health,Southeast Umverszty,Nanjmg 210009,China) 摘要：咀的】研究氧化型染发剂经皮吸收后对小鼠的亚慢性毒作用。【方法】 以氧化型染 发剂的主要成分对苯二胺(PPD)经双氧水氧化后的化合物为受试物，对小鼠每隔3天染毒 1次，进行为期1个月的经皮染毒。实验过程中采用一系列生物学指标观察小鼠的生长情况、 血象和肝肾功能的变化、内脏组织学改变和遗传毒性。【结果】PPD和H202混合物可影响 小鼠的肝肾功能，具有遗传毒性，能造成骨髓细胞染色体和DNA的损伤，并在受试剂量范 围内存在剂量-反应关系。【结论】频繁使用氧化型染发剂可能对机体具有潜在的危害。 关键词氧化型染发剂对苯二胺亚慢性毒性遗传毒性 thesubchroniocOilmice causedoxidizedhair Abstruct：【objective】Tostudy toxicRy by mixtureof main of dyes．[Methods]Theparaphenylenediamine(PPD)andH202(thegradlent oxidizedhatr andits to OiltheskinsofBalb／c 10timesina dyes oxidant)isappiledlay mice the seriesof indexesareselectedtoobservetheeffectsof month．Duringtestingperiod，a biological themixtrueto isshownthatno differenceinthe mice．[Results]It significant averagebedy bloodtestsand examinatmnsbetween and control weight，routine pathological experiment groups． Butthewet of andthebloodbiochemical and weightspleen,kindey indicators(GPTBUN)ale thancontrol inthe dose micronucleusincidencesin significanthiger group highergroups．The bloodincreasedin48hoursafter touchedhair firsttime．TheDNAstrand peripheral being dyes wereobservedin micemarrow results that breaks experimental cells．[Conclusion]Thesuggested