天然产物与microrna调控代谢综合征的研究进展-食品科学.pdfVIP

※专题论述 食品科学 2017, Vol.38, No.09 239 天然产物与microRNA调控代谢综合征的研究进展 1 1 1 1 1,2 1 郭 钦 ，白 洁，何宇轩，唐川惠，操庆国 ，董 英 （1.江苏大学食品与生物工程学院，江苏 镇江 212013 ；2.江苏农林职业技术学院生物工程系，江苏 句容 212000 ） 摘  要：代谢综合征已成为全球性的健康问题。microRNA （miRNA ）是一类能够调节基因表达的短单链內源非编 码RNA （约22 nt ），在转录后水平调节基因表达。miRNA在代谢综合征中发挥重要作用，药食同源的天然产物可 以通过调控miRNA 的活性和功能，改善糖脂代谢紊乱。本文主要综述miRNA在糖尿病、肥胖等代谢综合征的致病 机制中的研究进展，深入分析了药食同源的天然产物对miRNA 的调控机制，可为发掘miRNA在代谢综合征预防、 诊断、治疗中的潜在价值提供理论依据。 关键词：代谢综合征；microRNA ；天然产物  Progress in Research on Natural Products in MicroRNA Regulation for Metabolic Syndrome Improvement 1 1 1 1 1,2 1 GUO Qin , BAI Jie , HE Yuxuan , TANG Chuanhui , CAO Qingguo , DONG Ying (1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; 2. Institute of Biological Engineering, Jiangsu Polytechnic College of Agriculture and Forestry, Jurong 212000, China) Abstract: The metabolic syndrome has become a global health problem. microRNA (miRNA), a short single-stranded endogenously expressed RNA (approximately 22 nt), regulates gene expression at the post-transcriptional level. A lot of researches have shown that miRNA plays an important role in metabolic syndromes. Additionally, natural products which can be used as both food and medicine can modulate the activities and functions of miRNA to improve glucose and lipid metabolism disorders. Recent evidence described in this review highlights the significant role of miRNA in metabolic syndromes and how dietary factors may influence metabolic syndromes by modulating the activities and functions of miRNA. Key words: metabolic s