膳食多酚通过法呢醇x受体调节脂质代谢作用研究进展.pdfVIP

278 2017, Vol.38, No.07 食品科学 ※专题论述 膳食多酚通过法呢醇X受体调节脂质代谢作用 研究进展 1,2 2 2 2 2 1,* 肖 娟 ，张瑞芬 ，温叶杰 ，黄 菲 ，张名位 ，孙远明 （1.华南农业大学食品学院，广东 广州 510642 ；2.广东省农业科学院蚕业与农产品加工研究所，农业部功能食品重点 实验室，广东省农产品加工重点实验室，广东 广州 510610 ） 摘  要：高脂血症是许多慢性疾病的基础病因，由高脂血症引发的心脑血管病等慢性疾病已成为世界性的公共健康 问题。法呢醇X受体（farnesoid X receptor ，FXR ）在胆固醇、甘油三酯等代谢上发挥的重要作用使其有望作为治疗 高脂血症及相关疾病的药物靶点。膳食多酚具有良好的生物活性，可以通过调节FXR及其下游脂质代谢相关靶基因 的表达从而发挥调节脂质代谢的作用。本文综述了膳食多酚通过FXR调节脂质代谢的研究进展。 关键词：多酚；脂质代谢；法呢醇X受体 Dietary Polyphenols Modulate Lipid Metabolism by Regulating Farnesoid X Receptor: A Review 1,2 2 2 2 2 1,* XIAO Juan , ZHANG Ruifen , WEN Yejie , HUANG Fei , ZHANG Mingwei , SUN Yuanming (1. College of Food Science, South China Agricultural University, Guangzhou 510642, China; 2. Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Sericultural Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China) Abstract: Hyperlipidemia is an underlying cause of many chronic diseases, and the cardiovascular diseases and other chronic diseases partially caused by hyperlipidemia has become a worldwide public health problem. Farnesoid X receptor (FXR) plays a key role in the regulation of cholesterol and triglycerides metabolism. FXR might be a pharmacological target for the treatment of hyperlipidemia and related diseases. Dietary polyphenols can exert hypolipidemic activity by regulating FXR and its targeted genes. This paper