幽门螺杆菌对四环素耐药分析-内科学(消化病)专业毕业论文.pdfVIP

幽门螺杆菌对四环素耐药研究 中文摘要 目的通过对60 例幽门螺杆菌感染者临床分离菌株的培养和药敏试验,分析 幽门螺杆菌对四环素的耐药状况。 方法 检取2012 年11月至2013 年1月于我院行胃镜检查并取活检证实为幽 门螺杆菌感染的阳性患者60 例，采取胃粘膜组织进行体外幽门螺杆菌培养，通 过E-TEST 试纸条法测定四环素MIC 值，计算其耐药率并分析服药史对四环素耐 药的影响。 结果 四环素耐药的判定标准：MIC=1ug/mL。本实验60 例患者中，发现四 环素耐药者 3 例，四环素耐药率达 5%。运用统计学方法得出两组患者服药史存 在统计学差异（P0.05）。 结论 1.幽门螺杆菌对四环素的耐药率低。2.幽门螺杆菌对四环素耐药与既 往服药史密切相关，根治H.pylori 选择抗生素时，应考虑既往四环素使用情况 3.四环素耐药菌株较往年有升高趋势。 关键词 ：幽门螺杆菌；四环素；耐药;服药史。 1 Study of helicobacter pylori resistance to tetracycline Abstract Purpose To study helicobacter pylori resistance to tetracycline by the cultivation of clinical isolates and drug susceptibility test Method 60 patients with H. pylori infection came from Fujian Provincial Hospital in November 2012 to January 2013 and gastric mucosal tissue was taken for helicobacter pylori in vitro cultivation tetracycline MIC values were determined by the E-TEST criteria of tetracycline resistance was MIC = 1 ug/mL. Threse cases were found resistant to tetracycline and tetracycline resistant rate was 5%. There was a statistical differences in the two group patients vary by medication history (P 0.05). Conclusion 1. H. Pylori resistance to tetracycline is low 2. Helicobacter pylori resistance to tetracycline is closely related to the history of medicine, which should be considered in H.pylori treatment 3. Tetracycline resistant strains has a rising trend in resent years key words ：helicobacter pylori; Tetracycline; Drug resistance; History of medicine. 2 引言 幽门螺杆菌（Helicobacter pylori ，简称Hp）自1982年首先由Barry J. Mar shal 和J. Robin Warren 从胃黏膜活检样本中成功培养和分