ZnAl_BrO3_LDHs_K_省略_苯胺类化合物选择性氧化溴代的应用_王力耕.pdfVIP

网络出版时间：2017-09-08 14:50:08 网络出版地址：/kcms/detail/31.1321.O61450.002.html DOI: 10.6023/cjoc201705017 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE ZnAl-BrO3--LDHs/KBr 溴源在苯胺类化合物选择性氧化溴代的应用 王力耕*,a 陈璐焌a 章华隆a 余琴a (浙江工业大学化学工程学院 杭州 310014) 摘要 以醋酸/水为溶剂，用溴酸根插层的水滑石和溴化钾为溴源，室温下完成对苯胺类化合物的选择性氧化溴 代反应。成功合成苯胺类化合物的单溴代和多溴代的目标产物，并获得较高产率。本文考察了底物结构及反应条件 对反应选择性的影响。应用该溴源试剂，环境友好、操作简单、产率高，是一种合成溴代苯胺类化合物的新途径。 关键词 苯胺类; 卤化; 选择性; 芳香取代 Selective Oxidative Br omination of Anilines Using Potassium Bromide and ZnAl-BrO3—LDHs Wang, Ligeng*,a Chen, Lujun a Zhang, Hualong a Yu,Qin a (College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014) Abstract The oxidative bromination of anilines was realized with ZnAl-BrO3--LDHs/KBr as the bromine source at ambient temperature in acidic medium (AcOH/H O). High yields of monobrominated or polybrominated anilines 2 were achieved for a wide range of anilines. Both the substrate structure and the reaction conditions will signifi- cantly influence the reaction selectivity. The use of inexpensive reagents, environmentally benign and operationally simple process, and excellent yields make it a good alternative to the synthesis of bromoanilines. Keywords anilines; halogenation; selectivity;