CD34、p53在脑多形性黄色星形细胞瘤及巨细胞胶质母细胞瘤中的表达及意义.pdfVIP

刘政操 ，等 CD34、053在脑 多形性黄色星形细胞瘤及巨细胞胶质母细胞瘤 中的表达及意义 头 颈 肿 瘤 CD34、p53在脑多形性黄色星形细胞瘤及巨细胞胶质母细胞瘤中的表达 及意义 刘政操，李晓晗，李 悦，杨向红 ExpressionandeffectofCD34，p53inpleomorphicxanlhoaslrocylomaandgiantce glioblastoma LiuZhengeao，LiXiaohan，LiYue，YangXianghong Pathololg?,Department，ShengfingHospital ChinaMedicalUniversity，LiaoningShenyang110004，China． 【Abstract】 Objective：ToinvestigatetheexpressionofCD34，p53inpleolnorphicxamh0astr0。yt0ma(PXA)and giantcellglioblastoma(GCG)，andthecllnlc。ph0l。gc featuresanddifferentialdiagnosisofthetwotulnorsMeth- ods：ThirteencasesofPXA and11casesofGCG weremM yzed bylightlnicroscopy ilnlnunohistochelnieal staining Results：ThehistopathologicfeaturesofPXAwereanlnixtureofl~lononuclearcells，bizarremultinucleategiantcells， spindlecellsandlipid—richvacuolatedcellsThetmnorcellswereinfiltratedwithabundantlymphocytesandreticu— lulnfibers，littletmnornecrosisornucleardivisionimage ThehistopathologicfeaturesofGCG showedpleonlorphisln ofneoplasticcellalnongwhichlnainlywerebizsrrelnLdtinucleategiantcells，andlnuehnucleardivisionimage，hemor— rhageandnecrosis，infiltratedlymphocytesand reticululn fibersdistributedmoundthebloodvessels hnmunohisto— chelnical studydemonstratedPXA wasd~usepositivestainingforCD34，negativeforp53 W hileGCG wasnegative stainingforCD34，positiveforp53(60％ 一90％)Conclusion：Theclinicalandhistopathologicalcharacteristicsof PXA andGCG oreverysimilar Thedifferentialdiagnosisofthetwotmnorslnaitdy dependedonwhetherthereare foaln—liketmnorgiantcells，nucleardivisionimageandnecrosis，anddifferentexpressionofCD34 andp53 【Keywords】pleolnorphicxamh0astr0。yt0m ；giantcellglioblastolna；CD34；p53 ModernOncology2014，22(02)：0296—0299 【摘要】 目的：探讨 CD34、p53在多形性黄色星形细胞瘤 (PXA)及巨细胞胶质母细胞瘤 (GCG)中的表达情 况，以及两种肿瘤的临床病理特点、诊断及鉴别诊断。方法：对 l3例PXA及 11例 GCG进行临床病理学观察， CD34、