心脏瓣膜疾病与肺高压相关性的临床分析-中华老年多器官疾病杂志.docVIP

·临床研究· 心脏瓣膜疾病与肺高压相关性的临床分析 黄 文1, 丁 宁1, 张石江2, 张希龙1, 解卫平1, 王 虹1* （南京医科大学第一附属医院: 1呼吸内科, 2心胸外科, 南京 210029） 【摘 要】目的 分析心脏瓣膜疾病（HVD）与肺高压（PH）患者的临床资料，探讨两者的相关特征及导致PH发生的危险因素。方法 回顾性分析2010年4月至2011年10月在我科住院拟进行手术的256例具有完整临床资料的HVD患者资料，通过病史、体征结合二维心脏超声评估患者基本临床特征如肺动脉压力等，并根据肺动脉压水平分为非PH组（n＝＝＝＝＝＝＝R563.9 【文献标识码】 A 【DOI】 ? Clinical analysis on correlation of heart valvular diseases and pulmonary hypertension HUANG Wen1, DING Ning1, ZHANG Shi-Jiang2, ZHANG Xi-Long1, XIE Wei-Ping1, WANG Hong1* (1Department of Respiratory Diseases, 2Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China) 【Abstract】 Objective To investigate the relative features of heart valvular diseases (HVD) and pulmonary hypertension (PH), and the risk factors of PH by analyzing the clinical data of the patients with the 2 types of diseases. Methods A total of 256 HVD patients with complete clinical data receiving surgical treatment in our hospital from April 2010 to October 2011 were subjected in the study. Retrospective analysis was carried out on case history, signs, and results of echocardiography and so on. They patients were divided into non-PH group (n=157, pulmonary pressure 35 mmHg; 1 mmHg=＝=50, pulmonary pressure 35 to 50 mmHg) and PH group (n=49, pulmonary pressure 50 mmHg). Different statistical methods including multiple regressive analysis were used between those HVD patients with PH and without PH. Results In all of the 256 HVD patients, 49 patients were diagnosed with PH according to the diagnostic criteria of the European Society of Cardiology 2009. The HVD patients complicated with PH had an average age of 50.2 years, in a ratio of male to female of 18∶31. Heart function grade of New York Heart Association (NYHA) (OR=1.243), left atrial diameter LAD (OR=1.016) and the duration of heart failure (OR=1.018) were the risk factors of PH in HVD patients. Conclusion HVD is an important cause of PH. Significant differences are see