利用猪颅底血管网建立用于介入治疗的脑动静脉畸形-北华大学学报.PDFVIP

第15卷 第3期 北华大学学报(自然科学版) Vol.15 No.3 2014年6月 JOURNAL OF BEIHUA UNIVERSITY(Natural Science) Jun.2014 文章编号:1009-4822(2014)03-0329-05 DOI:10.11713/ j.issn.1009-4822.2014.03.011 利用猪颅底血管网建立用于介入治疗的 脑动静脉畸形栓塞模型实验研究 宁显宾,逄锦峰,丁照义,王雪鹏,王　 贺,纪祯龙,赵长福 (北华大学附属医院,吉林 吉林　 132011) 摘要:目的　 利用猪颅底微血管网建立用于介入治疗的动静脉畸形模型.方法　 使用液体胶或颗粒介入栓塞猪 cAVM模型,其中微导管的位置、栓塞剂的量及注射速度均模拟人体内介入栓塞的过程.通过模拟cAVM介入栓 塞过程,观察栓塞效果及并发症情况.结果　 此模型建造简单,通过血管造影可见到供血动脉、畸形血管团和引 流静脉.制备的模型均可承受全身麻醉、显微外科手术和血管内操作,没有不良后果.结论　 利用猪cAVM模型 进行新型栓塞剂的实验,操作者可通过此模型进行介入栓塞的训练,提高介入技术水平. 关键词:脑动静脉畸形;训练;颅底微血管网;模型 中图分类号:R332 文献标志码:A Experimental Research on the Establishment of Cerebral Arteriovenous Malformation Model for Endovascular Emblotherapy by Using Porcine Skull Base Capillary Network NING Xian-bin,PANGJin-feng,DINGZhao-yi,WANG Xue-peng, WANG He,JI Zhen-long,ZHAO Chang-fu (Affiliated Hospital of Beihua University,Jilin132011,China) Abstract:Objective To establish cerebral arteriovenous malformation model(cAVM) used in endovascular embolotherapy by utilizing porcine skull capillary network.Method The porcine cAVM model was established with liquid glue or particle embolization,in which the microcatheter position,dose,volume and injection rate of embolic agentweredeliberately variedto simulateresultsthat may beobservedin clinicalpractice.Theembolism effect and its complications were observed by the endovascular embolism of simulated cAVM.Results It was simple to establish the model.Supplying arteries,malformation vascular mass and draining veins could be seen through the angiography.The pigs used for the establishment of the model could tolerate the general anesthesia, microsurgery