自组装微纳材料的刺激响应性形貌演化及细胞毒性.PDFVIP

第9 卷 第6 期 Vol.9 No.6 2016 年 3 月 March 2016 自组装微/纳材料的刺激响应性形貌演化 及细胞毒性 张文博，高长有* （浙江大学高分子科学与工程学院，高分子合成与功能构造教育部重点实验室，杭州 310027 ） 摘要：自组装微/纳材料的形貌对其性质和功能起着重要作用，研究环境刺激调控微/纳材料形貌转变，有利于 促进对可控自组装、生命过程模拟等领域的研究。刺激响应性微/纳材料在细胞内发挥作用时，通常会发生化 学结构变化、形状转变或体积改变等，而这些物化性质的改变可能引起细胞毒性或影响细胞功能。因此，研 究细胞内刺激响应性微/纳材料的细胞毒性具有重要意义，对诊疗材料体系的构建也具有指导作用。本文总结 了微胶囊、微粒、聚合物胶束等自组装胶体结构的刺激响应性形貌演化及细胞毒性研究进展，并对其未来的 发展方向和应用进行了展望。 关键词：高分子材料学；自组装微/纳材料；综述；刺激响应性；形貌演化；细胞毒性 中图分类号：O631 文献标识码：A 文章编号：1674-2850(2016)06-0529-08 Stimuli-responsive morphology transformation and cytotoxicity of self-assembled micro/nano-materials ZHANG Wenbo, GAO Changyou (Key Laboratory of Macromolecular Synthesis and Functionalization , Ministry of Education, Department of Polymer Science and Engineering , Zhejiang University, Hangzhou 310027, China) Abstract: The morphology of self-assembled micro/nano-materials plays an important role in their properties and functions. So the research of stimuli-responsive morphology transformation of micro/ nano-materials can promote the insights into controlled self-assembly and simulation of biological self-assembly. When performing functions in living cells, the micro/nano-materials usually change their physiochemical properties such as shape and volume, which may cause cytotoxicity and influence on cell functions. Therefore, it is essential to study the stimuli-triggered cytotoxicity of micro/nano-materials, and this can be instructive for the construction of stimuli-responsive theranostic materials. This review