MCM2和Rb蛋白在胃癌中的表达及临床意义.pdf

现代肿瘤医学 2010年 08月 第 18卷第 08期 · 1595 · [13] MattsonMP，MeffertMK．RolesforNF—kappaBinnervecellsur． [15] BifuleoC，McDanielK，LengL，eta1．Tumorgrowth—promoting vival，plasticity，anddisease[J]．CellDeathDiffer，2006，13(5)： propertiesofmacmphagemigrationinhibitoryfactor[J]．Curr 852—860． Pharm Des，2008，14(36)：3790—3801． [14] ChiouSK，JonesMK，TamawskiAS．Survivin—allanti—apopto． [16] MaroneR，CmiljanovicV，GieseB，eta1．Targetingphosphoinosit— sisprotein：itsbiologicalrolesandimplicationsofrcancerandbe— ide3一kinase：movingtowardstherapy[J]．BioehimBiophysAc— yond[J]．MedSciMonit，2003，9(4)：PI25—129． ta，2008，12：159—185 (编校 ：李鹏超) MCM2和 Rb蛋白在 胃癌中的表达及临床意义 潘 峥 ，陈 军 ，覃冠德 ，覃思繁 ExpressionofMCM2andRbingastriccarcinomaandtheirclinicalsignificance PANZheng，CHENJun，QINGuan—de，QINSi—fan D‘epartmentofInternalMedicine，MaternityandChildrenHealthCareHospitalofGuangxiZhuangAutormmou~Region，Nanning 530003，China；DepartmentofPathology，theAffiliatedTumorHospitalofGuangxiMedcialUniversity，Nanning530021，China． A【bstract】 Objective：Toinvestigatetheexpressionofminichromosomemaintenanceprotein2(MCM2)andreti— noblastomasusceptibilitygene(Rb)ingastriccarcinomaandtheirclinicalsignificance．Methods：Immunohistochem— istywasemployedtodeterminetheexpressionofMCM2andRbin20casesofnormalgastricmucosatissue，30atypi— cal hyperplasiaofgastricmucosaand80casesofgastriccarcinomatissues．andtheresultswerequantifiedbycalcu— latingthelabellingindex(LI)．Results：LIofMCM2andRbinnormalgastricmucosatissue，atypicalhyperplasiaand gastriccracinomatissueswerestatisticallydifferent．LIofMCM2andRbwassignificantlycorrelatedwiththeclinical stage，invadeddepth，recurrenceoftumor，livermetastasis，andlymphnodemetastasis，butnotcorrelatedwithtumor size，andhistologicaltypes．Therewasasignificantlynegativ