Vitamin D and cancer - NCI Division of Extramural ：维生素D与肿瘤-校外NCI划分.ppt

Vitamin D and Cancer Lee Helman, M.D. Scientific Director for Clinical Research June 17, 2008 Outline Background Metabolism, catabolism, and VDR polymorphisms Recent Conflicting Studies NCI Funded Studies Future Studies/Needs Vitamin D in the news Recent NIH Conferences 2003 Vitamin D and Health in the 21st Century: Bone and Beyond May 2007 Vitamin D and Cancer: Current Dilemmas/Future Needs Sept 2007 Vitamin D and Health in the 21st Century: An Update Deeb et al (2007) Nature Reviews Cancer 7, 684-700 Vitamin D Implications in Cancer Conflicting Evidence Vitamin D emerged as a protective factor in a prospective, cross-sectional study of 3,121 adults aged ≥50 years (96% men) who underwent a colonoscopy. The study found that 10% had at least one advanced cancerous lesion. Those with the highest vitamin D intakes (645 IU/day) had a significantly lower risk of these lesions. Daily supplementation of calcium (1000 mg) with vitamin D (400 IU) for seven years had no effect on the incidence of colorectal cancer among postmenopausal women in the Women’s Health Initiative Wactawski-Wende et al (2006) NEJM, 354:7 More recently, a clinical trial focused on bone health in 1,179 postmenopausal women residing in rural Nebraska found that subjects supplemented daily with calcium (1,400-1,500 mg) and vitamin D3 (1,100 IU) had a significantly lower incidence of cancer over 4 years compared to women taking a placebo. Vitamin D and Cancer Incidence DCEG Vitamin D studies Examine the prospective relationship between the vitamin D status metabolite, 25-hydroxyvitamin D in serum and cancer mortality The study was conducted in more than 16,000 persons aged 17 and older who participated in the Third National Health and Nutrition Examination survey (NHANES III) Found total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans in persons younger than 70 or 70 years or older