干扰素-α治疗慢性乙型肝炎的疗效及其影响因素的(英文).pdfVIP

1741 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.9 MAY.2011 · · Study of Therapeutic Efficiency and Efficient Factor of Interferon for Chronic Hepatitis B WANG Hui, LI Jian -zhong, LIU Fu -hui, HOU Qing -shun, GUO Bao-ying (Medical College, Qingdao University, Qingdao, 266000) ABSTRACT Obj ective: To investigate the influencing factors of the efficacy of interferon α (IFN-α) on patients with chronic hep- atitis B (CHB). Methods: 46 cases of CHB patients were chosen in this study, who were treated with IFN-α for 48 weeks in Qingdao Hospital for Infectious Diseases from January 2006 to June 2009, which were divided into responding group and non-responding group according to the efficacy of IFN-α. The influence of host factors, viral loads and biochemical factors on the efficacy of IFN-α was de- tected. Results: The proportions of sex and the mean ages and courses of disease were similar in the two groups (P 0.05). The pre-treat- ment HBV-DNA loads were lower and the ALT levels were higher in responding group than those in non-responding group (P 0.05), while the responding rate of the patients with HBeAg positive was higher than that with HBeAg negative (P 0.05). The rate of HBV-DNA load decreased more than that of 2 log at the 12 weeks of treatment was significantly higher in the responding group than that in the non-responding group (P 0.05). Conclusion: The lower HBV DNA load, higher ALT level and HBeAg positive before treatment and the response of HBV DNA at the week 12 of treatment may be the predicting factors of the response at week 48