肌肉31P-MRS的临床进展.pdfVIP

176 · · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.1 JAN.2011 肌肉31P-MRS 的临床研究进展* 秦 斌 齐 静△ （南京医科大学附属第一临床医学院放射科江苏南京210029） 摘要：磁共振波谱分析(magnetic resonance spectroscopy MRS)是目前唯一无创性定量研究人体组织细胞代谢、生理生化改变的方 31 ( P-MRS) (Pi) (PCr) (ATP) 法。磁共振磷谱 可对无机磷 、磷酸肌酸 、三磷酸腺苷 等含磷高能化合物进行定量分析，是在体研究骨骼肌 能量代谢的有力工具。动态磷谱技术可测量肌肉在静息状态、收缩过程和恢复过程中细胞内高能磷酸化合物的变化，评价骨骼肌 做功时的能量的转换效率，实现对线粒体功能的无创性评价。本文将对肌肉磷谱的研究进展做综述，尤其侧重于动态磷谱的应 用，为以后利用磷谱客观研究肌肉相关疾病奠定良好的基础。 31P-MRS 关键词：磁共振磷谱（ ）；骨骼肌；氧化磷酸化；能量代谢 R445.2 A 1673-6273 2011 01-176-04 中图分类号： 文献标识码： 文章编号： （ ） Clinical Research of 31P-MRS for Skeletal Muscle* QIN Bin, QI Jing△ Dep artment of Radiology, the First Affiliated Hosp ital of Nanj ing Medical University, Nanj ing 2 10029, China （ ） ABSTRACT: As one type of Magnetic Resonance Spectroscopy (MRS), Phosphorus MR spectroscopy(31P-MRS) has special effect in the analysis of energy metabolism of human tissue and cell in vivo, it can quantitatively analyse of the concentrations of inorganic phosphate(Pi), phosphocreatine(PCr), adenosine triphosphate(ATP) and so on. so it plays an important role in the study of skeletal muscle and energy metabolism. Dynamic 31P-MRS technique can survey the change of high energy phosphate compounds in muscle cells during resting state, during and after exercise, evaluate energy conversion efficiency during mucle contraction. This paper reviewed the research of mucle 31P-MRS, particularly focused on the application of the dynamic 31P-MRS. It will lay