两种联合方案治疗2型糖尿病的成本-效果分析.docVIP

精品论文 参考文献 两种联合方案治疗2型糖尿病的成本-效果分析 葛震坤 (安徽省含山县人民医院内三科 238100) 【摘要】目的：比较两种联合方案治疗2型糖尿病的成本效果。方法：2型糖尿病62例，随机分为A组(格列美脲联合二甲双胍，33例)、B组(格列美脲联合吡格列酮，29例)，观察空腹血糖、餐后2小时血糖的变化，用药物经济学中的成本效果分析法对两种治疗方案进行评价。结果：血糖控制有效率、低血糖发生率两组无统计学差异(Pgt;0.05)，A组成本(1659.31元)低于B组(2036.45元)，差异有统计学意义(Plt;0.05),以成本较低的A组为参照，增量成本效果比B组为269.39，敏感度分析示两组药物降价10%后增量成本效果比B组为242.45。结论：格列美脲联合二甲双胍方案治疗2型糖尿病的成本效果优于格列美脲联合吡咯列酮方案。 【关键词】 2型糖尿病 格列美脲 二甲双胍 吡格列酮 成本-效果分析 【中图分类号】R587.1 【文献标识码】A 【文章编号】2095-1752（2014）18-0065-02 Cost - effectiveness analysis of two joint programs in the treatment of type 2 diabetes Ge Zhen-kun. Department of third Internal Medicine, the Peoples Hospital of Hanshan County, Hanshan 238100, Anhui 【Abstract】Objective To compare the cost-effectiveness of two joint programs in the treatment of type 2 diabetes. Methods 62 cases with type 2 diabetes were randomly divided into group A(glimepiride combined metformin ,33 cases)、group B(glimepiride combined pioglitazone,29 cases),the change of fasting blood glucose、2-hour postprandial blood glucose were observed , with the pharmacoeconomics cost-effectiveness analysis in the two treatment programs were evaluated. Results The effeciency of glycemic control、the incidence of hypoglycemia was no significant difference between two groups (Pgt; 0.05),Costs in group A(1659.31 Yuan) was less than in group B (2036.45 Yuan), with significant difference(P lt; 0.05) , with a lower cost of group A as a reference, the incremental cost- effectiveness ratio was 269.39 in group B,the sensitivity analysis shows,the incremental cost-effectiveness ratio after the two groups of drug prices 10% was 242.45 in group B . Conclusion glimepiride combined metformin in the treatment of type 2 diabetes was better than glimepiride combined pioglitazone in cost-effectiveness. 【Key words】type 2 diabetes glimepiride metformin pioglitazone cost - effectiveness analysis