化学发光法检测监测肝病患者肝纤维化及甲胎蛋白的动态变化.docVIP

精品论文 参考文献 化学发光法检测监测肝病患者肝纤维化及甲胎蛋白的动态变化 黄之文 (广东省高州市人民医院检验科 525200) 【摘要】目的: 探讨重型肝炎患者血清肝纤维化指标及甲胎蛋白(AFP)水平的动态变化。方法: 182例肝病患者应用化学发光法测定病毒性肝炎患者血清三型前胶原N端肽（PⅢNP）、Ⅳ型胶原（CⅣ）、层粘连蛋白（LN）、透明质酸（HA）、总胆汁酸(TBA)、甲胎蛋白(AFP)含量变化及AFP水平与肝功能指标的关系并比较联合检测对肝硬化临床价值。结果: 慢性乙型肝炎组、肝硬化、重症肝炎组肝纤维化四项及TBA、AFP指标均明显高于在正常对照组(Plt;0.05～0.01);并随疾病加重，水平增高；重型肝炎患者HA与PTA、ALB、TBIL有较好的相关性(r = -0372、-0.395、0.344，P均lt;0.05)；在两个指标的组合中以HA＋PⅢNP的诊断价值最高，在三个指标的组合中以HA＋PⅢNP＋CIV的诊断价值最高。结论: 动态监测血清HA、PⅢP、LN和AFP水平对肝病患者的预后判断有一定意义。 【关键词】肝纤维化指标 甲胎蛋白 动态变化 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2013）23-0382-02 Dynamic changes of serum fibrosis indices and alpha fetoprotein in patients with disease of the liver by chemiluminescence method Huang Zhiwen Department of labouratory,Gaozhou Hospital Gouzhou,Guandong 525200 China 【Abstract】Objective To investigate theDynamic changes of serum fibrosis indices and alpha fetoprotein in patients with disease of the liver.Methods: 182 cases with disease of the liver by using chemiluminescence immunoassays to detect the content of hyaluronic(HA)、laminin(LN)、typeШprocollagen aminopeptide(PШNP)、collagen(C-Ⅳ)、hyaluronic acid (HA), total bile acid (TBA), and alpha-fetoprotein (AFP), The content of AFP relationship between liver function and compare the clinical value of combined detection of liver cirrhosis.Results The content of serum fibrosis and TBA, AFP in chronic hepatitis B, cirrhosis, severe hepatitis were significantly higher than those in normal control group (Plt;0.05～0.01); by with elevated in disease, levels; The content of HA with PTA, ALB, TBIL have a good correlation (r = -0372, -0.395, 0.344, P lt;0.05);The index of HA combination with PⅢNP diagnostic value were highest,The index of HA combination with P NP + CIV. diagnostic value were highest. CONCLUSION: It is definitely valuable to dynamically inspect serum HA，PⅢP， LN and AFP level for the prognosis of liver cirrhosis. 【Key words】 liver cirrhosis liver fibrosis alpha-fetopr