双相抑郁患者经丙戊酸钠与西酞普兰联合利培酮方案治疗的临床效果探讨.docVIP

精品论文 参考文献 双相抑郁患者经丙戊酸钠与西酞普兰联合利培酮方案治疗的临床效果探讨 　　王心蕊 李 璐 　　【摘 要】 目的 分析双相抑郁患者经丙戊酸钠（VPA）与西酞普兰（CIT）联合利培酮（RIS）方案治疗的临床效果。方法 回顾性分析我院2013年2月至2015年12月期间收治的90例双相抑郁患者的临床资料，按照入院顺序将所有患者分为两组，即：观察组（45例）与对照组（45例）。观察组与对照组均给予CIT联合VPA治疗14d；14d之后观察组给予RIS、CIT、VPA联合治疗，对照组仍给予CIT联合VPA治疗，持续治疗8周。选用临床疗效总评量表病情严重程度（CGI-SI）、汉密尔顿17项抑郁量表（HAMD-17）进行评定。对比两组患者治疗之前与治疗之后各个时间点的CGI-SI评分及HAMD-17评分，同时对比两组治疗总有效率。结果 观察组治疗8周后，治疗总有效率显著优于对照组，差异有统计学意义（P＜0.05）；观察组??疗4周后，HAMD-17评分显著优于对照组，差异有统计学意义（P＜0.05）；观察组治疗8周后，CGI-SI评分显著优于治疗之前，治疗前后差异有统计学意义（P＜0.05）；观察组治疗8周后，CGI-SI评分与对照组无显著差异，无统计学意义（P＞0.05）。结论 双相抑郁患者经丙戊酸钠与西酞普兰联合利培酮方案治疗的临床效果十分显著，值得在临床治疗中推广应用。 　　【关键词】 利培酮； 西酞普兰； 丙戊酸钠； 双相抑郁； 临床效果 　　 　　To investigate the clinical effect of bipolar depression patients with sodium valproate and citalopram combined with risperidone therapy 　　 　　【Abstract】 objective Analysis of patients with bipolar depression after sodium valproate (VPA) and citalopram (CIT) combined with risperidone (RIS) regimen in the treatment of the clinical effect. Methods Retrospective analysis of the clinical data of 90 patients with bipolar depression patients admitted to our hospital from February 2013 to December 2015, according to the order of admission, all patients were divided into two groups, namely: the observation group (45 cases) and control group (45 cases). The observation group and the control group were treated with CIT combined with VPA 14d 14d after treatment; the observation group was given RIS, CIT, VPA combined treatment, the control group was treated with CIT combined with VPA therapy, the therapy lasted for 8 weeks. The CGI severity (CGI-SI), the 17 item Hamilton Depression Scale (HAMD-17) assessment. Compared two groups of patients before and after treatment at different time points of CGI-SI score and HAMD-17 score, compared the total efficiency of the two groups. Results The observation group after 8 weeks of treatment, the total efficiency of treatment was significantly better than the control group, the difference was s