F-FDGPETCT在非霍奇金淋巴瘤疗效评价中的应用价值.PDFVIP

上海医学影像 2009 年 12 月第 18 卷第 4 期 Shanghai Medical Imaging, 2009, Vol .18, No .4 - 273 - 18F-FDG PET/CT在非霍奇金淋巴瘤疗效评价中的应用价值 敏 华逢春　任树华　冯晓源　黄　　　左传涛　管一晖　赵　军 吉吉 心 18 【摘要 】 目的　探讨 F-FDG PET/CT显像对非霍奇金淋 巴瘤治疗疗效的价值 。方法　 收集2004.9~2008.11在我 院PET 中心 接 受至 少2 次PET/CT检查, 分为初诊 的在PET/CT扫描前 未治疗非霍奇金淋 巴瘤组(A组)或经过放 疗及化疗后 的治疗组(B组) 为研 究对 象。所有病例 随访至 少6个月。结果　 未治疗的非霍奇金淋 巴瘤组的32例 中, 3例颅 内淋 巴瘤 中2例在9个月 内复发; 21例 经过 6个疗程化疗后PET/CT为 阴性, 仅有1例 复发 (5%); 1例3个疗程化疗后SUV 降低达92.9% 的化疗效果佳; 而8例PET/CT 阳性者预后 不理想。治疗组病例 中, PET/CT 阴性的11例NHL, 复发3例(27%); 而PET/CT 阳性的25例 中, 19例复发(76%), PET 阳性组的肿瘤复 18 发与 阴性组差异有显著性(P＜0.05) 。结论　本研 究表 明 F-FDG PET/CT显像 能很好 的评价非霍奇金淋 巴瘤的治疗效果, 且可早 期预测治疗效果及预后 。 【关键词】脱氧葡萄糖; 体层摄影术, X线计算机; 正电子发射计算机; 非霍奇金淋巴瘤 18F-FDG PET/CT evaluation of response to treatment in non-Hodgkin lymphoma HUA Feng-chun, REN Shu-hua, FENG Xiao-yuan, HUANG Zhe-min, ZUO Chuantao, GUAN Yihui, ZHAO Jun (PET Center and Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China) 【Abstract 】 Objective To evaluate the usefulness of 18F-FDG PET/CT imaging in monitoring the response to treatment of non- Hodgkin lymphoma (NHL). Methods From September 2004 to November 2008, patients performed at least twice PET/CT exams in our center who were diagnosed as NHL or after radiotherapy and chemotherapy. Sixty-eight cases were divided into 2 groups. Group A with 32 cases who had not performed chemotherapy or radiotherapy before PET/CT scans, and Group B with 36 cases who had got various cycles of chemotherapy or radiotherapy. All cases were followed up at least 6 months. Results Among group A, the 32 cases had performed 78 PET/CT scans, 2 of 3 cases with primary central nerves lymphoma had relap