多系统萎缩不同亚型认知功能障碍的临床研究.docVIP

精品论文 参考文献 多系统萎缩不同亚型认知功能障碍的临床研究 （1新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830011) (2大连市金州区第一人民医院神经内科 辽宁 大连 116100） 【摘要】 目的：探讨多系统萎缩（multiple system atrophy，MSA）患者不同亚型之间认知功能障碍的临床特点。方法：随机选择MSA患者30例，其中MSA-P型患者18例，MSA-C型患者12例，以及30例健康对照组。采用简易智能量表、蒙特利尔认知评估量表测评病例组患者的认知功能损伤，采用统一的多系统萎缩评分量表对病例组患者的病情的严重程度进行评估。结果：MSA-P型与MSA-C型相比较，在视空间/执行能力、命名、语言、抽象思维、延迟记忆、定向力方面，MSA-P组评分均低于MSA-C组，两组评分差异有统计学意义。结论:MSA-P型较MSA-C型患者认知功能障碍受损明显。 【关键词】 多系统萎缩；认知功能障碍 ；蒙特利尔认知评估量表；简易精神状态量表；统一的多系统萎缩评分量表 【中图分类号】R74 【文献标识码】A 【文章编号】2095-1752（2015）35-0024-02 A clinical features of cognitive impairment in different subtypes patients with multiple system Atrophy ZZhu Jing, Kong Ming. Department of Neurology, the Fifth Hospital Affiliated to XinJiang Medical University, XinJiang Urumqi 830011, China 【Abstract】Objective To explore the clinical features of cognitive dysfunction in different subtypes patients with multiple system Atrophy. Methods The studies of medical records of 30 consecutive patients (18 patients with MSA-P and 12 patients with MSA-C) admitted into our neurology ward. Another 30 healthy old people were chosen as the control group. Cognitive function was assessed by mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA). Patientsrsquo; condition was assessed by Unified multiple system atrophy rating scale (UMSARS). Results There was significant difference between the two groups, the visuospatial/executive function, nomenclature, language function, abstract thinking, delayed recall and orientation scores of MSA-P group were lower than MSA-C group. Conclusions The more cognitive impairment in MSA-P than MSA-C. 【Key words】 Multiple system atrophy; Cognitive dysfunction; MMSE; MoCA ; UMSARS 多系统萎缩（multiple system atrophy，MSA）由Oppenheimer[1]于1969年首次提出，是一组成年发病的、原因不明的、散发性的神经系统变性疾病。根据2008年修订的MSA第二次专家共识诊断标准[2]，将MSA分为以帕金森样症状为主的MSA-P型;以小脑性共济失调为主要表现的MSA-C型。目前在MSA诊断标准中将痴呆作为临床诊断排除标准之一。随着国内外对MSA研究的逐渐深入，人们开始意识到MSA患者可能存在广泛而严重的认知功能障碍。因此，本研究探讨多系统萎缩（multiple