多索茶碱联合甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期疗效观察.docVIP

精品论文 参考文献 多索茶碱联合甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期疗效观察 徐莉莉1 高强1 马兆猛2 刘梅1 相茹1 顾加双1 梁娜1 　　（1解放军第149医院呼吸科 江苏 连云港 222042） 　　（2 Hansoh制药有限公司 江苏 连云港 222047） 　　【摘要】 目的：观察联合注射用甲波尼龙琥珀酸钠和注射用多索茶碱治疗慢性阻塞性肺疾病急性加重期（AECOPD）的治疗作用。方法：将50例COPD急性加重期患者随机分为两组，试验组给予注射用甲泼尼松琥珀酸钠80mg联用注射用多索茶碱0.2g,2/日;对照组给予甲泼尼松琥珀酸钠80mg联用氨茶碱0.25g，2/日,治疗期间同时予以抗菌素预防感染，疗程均为7d，试验前后分别测定肺功能及血气分析并观察患者试验前后临床症状、体征变化。比较前后的疗效。结果：治疗后，2组的FEV1%，FEV1%/FVC,FEV1/预计值（%）、动脉血氧分压（PO2）、动脉二氧化碳分压（PCO2）、临床症状、体征较试验前均有明显改善（P＜0.05）.结论：多索茶碱联用甲波尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期优于氨茶碱联用甲波尼龙琥珀酸钠。 　　【关键词】慢性阻塞性肺疾病；多索茶碱；甲泼尼龙琥珀酸钠 　　【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2015）11-0044-02 　　 　　Doxofylline combined with Methylprednisolone sodium succinate in treatment of acute exacerbation of chronic obstructive pulmonary disease Xu Lili1,Gao Qiang1,Ma Zhaomeng2 ,Liu Mei1 ,Xiang Ru1, Gu Jiashuang1, Liang Na1 1.Department of Respiration, The 149th Hospital of PLA,Jiangsu, Lianyungang, 222042,China ;2. Hansoh Pharmaceutical Co., Ltd Jiangsu,222047,China 　　【Abstract】Objective To observe the effect of combined injection of methylprednisolone sodium succinate and Doxofylline for Injection in treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) treatment. Methods 50 cases of AECOPD patients were randomly divided into two groups. The experimental group received injections of methylprednisolone sodium succinate 80mg combined with doxofylline 0.2g twice a day, while the control group received methylprednisolone sodium succinate 80mg combined with aminophylline 0.25g twice a day. The treatment lasted for seven days. Antibiotics were used during the treatment to prevent infection. Before and after the test, the lung function and blood gas analysis were measured and the clinical symptoms and signs of patients were observed. Compare the efficacy before and after. Results After treatment, the FEV1%, FEV1% / FVC, FEV1 / expected value ( % ) , arterial partial pressure of oxygen (PO2), arterial partial pres