多索茶碱联合甲泼尼龙及多沙普仑在慢性阻塞性肺疾病2型呼吸衰竭的应用.docVIP

精品论文 参考文献 多索茶碱联合甲泼尼龙及多沙普仑在慢性阻塞性肺疾病2型呼吸衰竭的应用 （贵州医科大学第二附属医院呼吸内科 贵州凯里 556000） 　　【摘要】目的：探讨多索茶碱联合甲泼尼龙及多沙普仑在慢性阻塞性肺疾病2型呼吸衰竭的应用效果。方法：将慢性阻塞性肺疾病2型呼吸衰竭患者74例随机分为两组，对照组37例采用甲泼尼龙治疗，观察组37例采用多索茶碱、甲泼尼龙、多沙普仑联合治疗，比较两组临床指标改善情况、治疗效果及不良反应。结果：治疗后，两组PaO2、FEV1增加（P＜0.05）。两组PaCO2、呼吸频率、心率降低（P＜0.05）。观察组PaO2、FEV1、治疗总有效率高于对照组（P＜0.05）。观察组PaCO2、呼吸频率、心率低于对照组（P＜0.05）。观察组呼衰纠正时间少于对照组（P＜0.05）。两组不良反应（过敏反应、兴奋失眠、胃肠道反应）比较，差异无统计学意义（P＞0.05）。结论：??索茶碱联合甲泼尼龙及多沙普仑治疗慢性阻塞性肺疾病2型呼吸衰竭是安全有效的，值得临床推广使用。 　　【关键词】多索茶碱；甲泼尼龙；多沙普仑；慢性阻塞性肺疾病；呼吸衰竭 　　【中图分类号】R453 【文献标识码】A 【文章编号】1007-8231（2016）21-0115-02 　　Application of doxofylline combined with methylprednisolone and doxapram in treatment of chronic obstructive pulmonary disease type 2 respiratory failure Huang Ying. 　　Department of Respiratory Medicine, The Second Affiliated Hospital of Guizhou Medical University, 556000,China 　　【Abstract】Objective To investigate application effect of doxofylline combined with methylprednisolone and doxapram in treatment of chronic obstructive pulmonary disease type 2 respiratory failure. Methods 74 patients with chronic obstructive pulmonary disease type 2 respiratory failure were randomly divided into two groups.37 patients treated methylprednisolone as control group. 37 patients treated doxofylline ,methylprednisolone, doxapram as observation group. Improvement of clinical indexes, therapeutic effect, adverse reactions were compared between two groups. Results After treatment, PaO2 and FEV1 increased in two groups(Plt;0.05). PaCO2, respiratory rate , heart rate decreased in two groups(Plt;0.05). PaO2 , FEV1, total effective rate in observation group were higher than control group(Plt;0.05). PaCO2, respiratory rate , heart rate in observation group were lower than control group(Plt;0.05).Correct time of respiratory failure in observation group was less than control group(Plt;0.05). Compared with adverse reactions (allergic reactions, insomnia, gastrointestinal reactions) in two groups, the difference