妊娠高血压患者褪黑素与ET、NO水平变化及意义.docVIP

精品论文 参考文献 妊娠高血压患者褪黑素与ET、NO水平变化及意义 董春艳1 单红英2 史秋兰3 　　1.卢龙县医院妇产二科 066400；2.秦皇岛市第三医院066000；3.抚宁县医院妇产科 066300 　　摘要：目的 通过检测妊娠高血压疾病患者褪黑素（MT）和ET、NO水平，探讨其与妊娠高血压疾病相关性。妊娠期高血压疾病组80例，其中轻、重度子痫前期患者各40例，正常妊娠晚期孕妇40例，选择同期40例正常非孕妇女为对照组，检测其血清ET、NO及MT值。结果 与对照组和正常晚期妊娠组比较，妊娠期高血压疾病组血清ET水平均明显升高，而MT、NO水平显著下降，差异有统计学意义（P lt; 0.01）；与轻度子痫前期组比较，重度子痫前期组ET水平升高，MT、NO下降，差异均有统计学意义（P lt; 0.01）。各组血清MT水平与血清NO水平呈正相关，与ET水平呈负相关；ET水平与NO水平呈负相关。结论 妊娠高血压疾病患者血清MT、ET、NO水平与妊娠高血压疾病及病情发展密切相关。 　　关键词：妊娠高血压疾病；MT；ET；NO 　　Abstract：Objective　 To investigate the relationship between disease severity and serum tumor necrosis melatonin、nitricoxide and endothelin levels in the patients with hypertensive disorder complicating pregnancy.patients with mild preeclampsia and severe preeclampsia in the research group（each 40 cases）and normal late pregnancy women、normal women（each 40 cases）in the control group were selected and the serum tumor necrosis melatonin、nitricoxide and endothelin levels were detected.The plasma TNF-a，IL-6 levels were significantly higherin patients w ith hypertension disorders in pregnant than those in the normal late pregnancy and normal reproductive age women（Plt;0.01），while the plasma MT、NOlevels were significantly lower（Plt;0.01）The plasma ET levels were significantly higher in serious eclampsism groups than those in light degree eclampsism，while the plasma MT levels were sign ificantly lower（Plt;0.01）??The plasma MT was a positive correlation with NO，while the plasma NO was a negative correlation with ET；The plasma MT was negative correlation with the plasma ET.Conclusion：The levels of MT，NO and ET are closely correlation w ith the morbidity and the progression of diseasewith hypertensiondisorders in pregnant. 　　Key words：Hypertensive disorder complicating pregnancy；melatonin；endothelin；nitricoxide 　　妊娠高血压疾病（HDCP）是妊娠中晚期发生的以高血压、水肿、蛋白尿为主要特征的征候群，尽管国内外对其发病机制作了大量的研究，但病因仍不明确[1]。目前，妊娠高血压疾病的主要发病机理是内皮细胞激活与损伤学说，本研究通过检测妊娠高血压疾病患者褪黑素（Melatonin，MT）、ET、NO和水平，探讨其与妊娠高血压疾病及其严重程度之间的关系。 　　1 资料与方法 　　1.1临床资料 随机选