宫颈癌术后放化疗的研究进展.docVIP

精品论文 参考文献 宫颈癌术后放化疗的研究进展 吴星娆 叶岚 郑洁 艾毅钦（通讯作者） 　　（昆明医科大学第三附属医院 云南省肿瘤医院放射肿瘤治疗中心 云南 昆明 650118） 　　【摘要】 宫颈癌是最常见的妇科恶性肿瘤，也是严重影响妇女身心健康，威胁妇女生命的重要疾病之一[1]。我国每年新发宫颈癌病例13.5万，约占全球发病数量的1/3，为我国妇科恶性肿瘤第一位[2]。宫颈癌根治术后的治疗受分期及危险因素的影响。对于分期早，如IA1期没有危险因素的患者，可以选择观察，但此类患者极少；大部分术后患者具有中危或高危因素，需要进一步治疗，中危因素即参照2015年指南Sedlis标准（肿瘤较大、侵犯宫颈间质、淋巴脉管间隙阳性）患者术后加用盆腔外照射放疗。本文就宫颈癌术后辅助放化疗的研究做一综述。 　　【关键词】 宫颈癌; 术后; 同步放化疗; 放疗 　　【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2015）22-0007-03 　　 　　Research progress of postoperative radiotherapy and chemotherapy in cervical cancer 　　Wu Xingrao, Ye lan,Zheng jie,Ai Yiqing. The Third Affiliated Hospital of Kunming Medical University， Yunnan Provincial Cancer Hospital Radiation Oncology Treatment Center， Kunming 650118,China 　　【Abstract】Cervical cancer is not only the most common malignant tumor in gynecology, but also one of the important disease which threat to womens physical and mental health. With the improvement of diagnoses and treatment, and peoplersquo;s awareness, more and more cervical cancer patients get the chance of operation. How to improve the curative effect and postoperative treatment become a concern. Curative effects of radical therapy after operation is associated with stage and risk factors of cervical cancer. In early stage, such as FIGO stage IA1 with no risk factors , patients can be observed, most of the postoperative patients with intermediate or high risk factors need to further treatment . Patients with intermediate risk factors need to pelvic external beam radiotherapy after surgery according to the 2015 guide sedlis standard (larger tumors, invasion of cervical matter, lymph vascular space). Risk factors include: ①local tumor size (diameter gt; 4cm); ② cervical deep myometrial invasion gt;1/3; ③pelvic or para aortic lymph node metastasis; ④ resection margin positive,⑤ parametrial infiltration;⑥ pathological grade in the grade III;⑦lymph vascular space invasion; ⑧the special pathological types (gland carci