赤土茯苓苷对试验性胃溃疡的保护作用-天津中草药杂志社.PDFVIP

　Chinese Traditional and Herbal Drugs　2000 31 4 ·277· * * * * ( 830000)　　杜　鹏 　薛　洁　周承明 　毛新民 　　( Smi)。 Wistar, 3 。 : Smi、。 Smi: 、( Smi 100、 200 mg/kg　P 0. 05; Smi 300 mg /kg P 0. 01); - - ( 0. 05), ( 100、 200 / 0. 05, 300 / Se GSH Px P DA Smi mg kg P Smi mg kg P 0. 01);、 pH( Smi 100、 200 mg /kg P 0. 05, Smi 300 mg /kg P 0. 01)。 ( 0. 05);( 0. 05)。 : P P Smi 。 Se-GSH-Px、 DA,。 　　　　 Protective Effects of Smiglabran on Experimental Animal Models of Gastric Ulcer 　　Department of Pharmacy, Affiliated Hospital of TC , Xinjiang University of edical Sciences ( Wulumuqi 830000)　 Du Peng Xue Jie Zhou Chengming and ao Xinmin, , Abstract　　 Protective effects of smiglabran ( S ), a glucoside isolated from Smilax g labra Roxb., on experimental models of peptic ulcersinduced by reserpine, stress and pylorus ligationwere studied. S at doses of 100～ 300 mg/kg resulted in a decrease of peptic ulceration index and number of blood clots, increased the Se-GSH-Px activity of gastric mucosa, lower the amount of malondialdehyde ( DA) and elevated gastric fluid and pH levels as compared with the normal saline control, but without effects on pepsin and gastrointestinal peristalsis. These results indicated that S could obviously prevent peptic ulceration probably through its actions to enhance Se-GSH-Px activity and lower DA and free radical damage on gastric mucosa. Key words　　 Sm ilax g labra Roxb.　 smiglabran ( S )　 peptic ulcer protection against peptic ulceration 　　(L il iaceae) 1. 3　:( 1× 6. 3,), S milax g labra Roxb. , (CHC-212 Olympus,), 751-G ,《》,。 (),WFJ-1(722) 、、,、、