人羊膜上皮细胞及其免疫调节功能-中国细胞生物学学报.PDFVIP

网络出版时间：2015-07-02 09:51 网络出版地址：/kcms/detail/31.2035.Q0951.004.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(7): DOI: 10.11844/cj cb.2015.07.0028 人羊膜上皮细胞及其免疫调节功能 1 1* 2* 司家文 沈国芳 郭礼和 1 2 ( 上海交通大学医学院附属第九人民医院口腔颅颌面科, 上海200011; 中科院生化细胞所, 上海200333) 摘要 人羊膜上皮细胞, 作为一种处于特殊分化阶段和组织来源的干/祖细胞, 不仅可在体内 外特定环境下向三个胚层组织分化, 还表现出独特的免疫豁免和免疫调节功能, 使其在细胞治疗、 组织再生领域展现出广阔的研究和应用前景。随着人羊膜上皮细胞免疫调节及其机制研究的深入, 其在免疫相关疾病治疗方面的研究和应用价值逐渐突显。在此, 笔者就近年来人羊膜上皮细胞细 胞生物学特性及其免疫调节功能的研究进展进行综述, 以期为相关领域研究的开展提供参考。 关键词 人羊膜上皮细胞; 多能性; 免疫调节; 细胞治疗 Human Amniotic Epithelial Cell and Its Immunomodulatory Effects 1 1*, Guo Lihe2 * Si Jiawen , Shen Guofang 1 ( Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shang- 2 hai 200011, China; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200333, China) Abstract Human amniotic epithelial cells, a special type of stage and tissue specific stem/progenitor cells, have been shown to possess multi-differentiation potential under certain circumstances in vitro and in vivo, and exhibit unique immune privilege characteristics and immunomodulatory effects, Wh