山泽参黄汤治疗非酒精性脂肪性肝炎的疗效观察.docVIP

山泽参黄汤治疗非酒精性脂肪性肝炎的疗效观察 薛江洲 吴红梅 （江苏省丹阳市中医院 江苏丹阳 212300） 【摘要】目的 研究山泽参黄汤治疗非酒精性脂肪性肝炎(NASH)的疗效及安全性。方法 63例NASH患者随机分为对照组和治疗组，对照组采用复方益肝灵治疗，每日3次,每次4片。治疗组给予山泽参黄汤口服，每日1剂,每剂煎服2次，连用3个月。治疗前及治疗结束后分别测量体重指数、腰/臀比，检测空腹血糖、血脂、胰岛素、肝功能，计算胰岛素抵抗指数{IRI}、肝脏B超积分。结果 治疗3个月以后，两组病人血糖、血脂、肝功能和B超积分均有不同程度的改善，但治疗组在降低TG、LDL-C、FBS、IRI和改善肝功能方面显著优于对照组.两组总有效率分别为84.4％和61.4％,治疗组显著高于对照组（P ＜0.05)。结论 山泽参黄汤治疗NASH安全有效，能减轻脂肪肝，改善肝功能。 【关键词】非酒精性脂肪性肝炎 山泽参黄汤 体重指数 胰岛素抵抗指数 肝功能 腰/臀比 【中图分类号】R243 【文献标识码】A 【文章编号】2095-1752（2012）24-0141-03 Evaluation of therapeutic efficacy of Shan-Ze-Shen-Huang decoction for patients with non-alcoholic steatohepatitis Xu Jiang-Zhou, Wu Hong-Mei Danyang TCM Peoples Hospital 【Abstract】 Objective To evaluate the therapeutic effect of Shan-Ze-Shen-Huang decoction for patients with non-aleoholie steatohepatitis(NASH).Methods 63 cases with NASH were randomly divided into two groups.Group A including 32 patients were treated with Shan-Ze-Shen-Huang decoction，a mixture composed of Dioscorea opposita Thunb, Alismatis Rhizoma, Dan Shen and Coptis chinensis Franch,for 3 months. Group B(control group) treated with Fufang Yiganling Tablet 4# tid, for three months.Before and the end of treatment，the data of clinical symptoms and physical signs，Body mass index(BMI)，Waist-hip ratio(W/H R) were recorded, and fasting blood glucose(FBS)，insulin(FINS), lipids，liver function tests and liver ultrasonographic image score were serially measured.Results As compared with basal values，both groups after three-month treatment showed an improvement to some extent in FBS，lipids，insulin resistance index (IRI),liver function and hepatic ultrasonographic score，but Group A was significantly superior to group B in reduction of TG,LDL-C,FBS,and in ameliorating liver function.The total effective rate in group A(84.4％) was much higher than in in control group(61.4％)，P ＜0.05.Conclusion Shan-Ze-Shen-Huang decoction was an effective and safe medicati