几种常用的肿瘤标志物在乳腺癌中的临床应用价值.docVIP

精品论文 参考文献 几种常用的肿瘤标志物在乳腺癌中的临床应用价值 魏永梅1 马芝金1 陈铁军2 　　(1本溪市中心医院检验科 117000) 　　(2本溪市中心医院肿瘤内科 117000) 　　【摘要】目的 探讨常用的肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、糖类抗原15-3(CA15-3)在乳腺癌诊断及疗效评价中的应用价值。方法 采用电化学发光法检测102例乳腺癌患者、38例乳腺良性肿瘤患者、78例健康人血清中4种肿瘤标志物的水平。结果 CEA、CA125、CA15-3、CA19-9等4种标志物在乳腺癌患者血清中的含量均高于乳腺良性肿瘤患者和健康人，具有统计学意义( Plt;0.05)；4种标志物对乳腺癌诊断的敏感性随着肿瘤分期的加重而逐渐提高，但是仅CEA和CA15-3诊断乳腺癌的阳性率相对较高；联合检测CEA+ CA15-3诊断乳腺癌的性价比最高；乳腺癌经过手术或化疗后血清CEA、CA15-3、CA125下降明显，CA19-9下降不明显。结论 血清肿瘤标志物尤其是CEA和CA15-3对于乳腺癌的诊断和监测具有良好的临床应用价值。 　　【关键词】肿瘤标志物 乳腺癌 联合检测 　　【中图分类号】R737.9 【文献标识码】A 【文章编号】1672-5085（2013）40-0007-02 　　Diagnostic and therapeutic effect Value of Serum Tumor Markers for Breast Cancer 　　Wei Yong mei1, Ma Zhi jin2, Chen Tie jun3 　　（1 Blood Transfusion Department，Ben xi Central Hospital, 2 Clinical Laboratory，Ben xi Central Hospital, 3 Medical Oncology Department，Ben xi Central Hospital，117000, Liao ning） 　　【Abstract】Objective To evaluate the clinical value of CEA、CA125、CA15-3 and CA19-9 used alone or in combination for the diagnosis and therapeutic evaluation of breast cancer. 　　Methods The serum levels of four tumor markers：CEA、CA125、CA15-3 and CA19-9 were detected by Elecsys 2010 electrochemiluminescence analysator in 102 patients with breast cancer，38 patients with breast benign tumor and 78 healthy adults．Results The serum levels of the four tumor markers were significantly higher in breast cancer patients than in breast benign tumor patients and healthy adults( plt;0.05). We revealed an increasing tendency in serum tumor marker levels, along with the worsening of the breast cancer stages. Conclusion These results indicate that the serum tumor markers, especially serum CEA and CA15-3 have good clinical values for the diagnosis and surveillance of breast cancer． 　　【Key words】tumor marker breast cancer combined detection 　　乳腺癌是严重威胁女性健康的重要杀手，其发病率呈逐年上升的趋势。早期诊断、疗效评价及监测复发对于提高乳腺癌的防治水平具有十分重要的意义。肿瘤标志物是一类反映肿瘤存在的物质，其存在和量变可以提示肿瘤的性质，