非编码RNA-及其在组织工程中的潜在应用2989.pdfVIP

Engineering 3 (2017) 3–15 Contents lists available at ScienceDirect Engineering journal homepage: /locate/eng Research Tissue Engineering—Review Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering Shiying Li, Tianmei Qian, Xinghui Wang, Jie Liu, Xiaosong Gu* Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China a r t i c l e i n f o a b s t r a c t Article history: Received 3 November 2016 Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding Revised 19 December 2016 RNAs (ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate Accepted 11 January 2017 cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue Available online 16 February 2017 engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth Keywords: research on the regulation and delivery of ncRNAs may improve their application in tissue engineering. Tissue engineering The aim of this review is to outline essential ncRNAs that are related to tissue engineering for the repair : Non