莫西沙星治疗皮肤感染的随机双盲对照临床研究.PDFVIP

中国皮肤性病学杂志2002 年 11 月第 16 卷第 6 期　　Chin J Derm Venereol ,Nov 2002 ,Vol. 16 ,No. 6 3·79 · 莫西沙星治疗皮肤感染的随机双盲对照临床研究 曹育春 ,陈兴平 ,徐祖森 　　[摘 　要] 　目的 　评价莫西沙星治疗轻中度急性无合并症的皮肤感染者的安全性和有效性。方法 　采用随机双盲 平行对照方法 ,对莫西沙星 400 mg 1 次/ d 口服与左旋氧氟沙星200 mg 2 次/ d 口服进行对比观察。结果 　治疗结束后第 ( ) 1 天 ,符合方案人群 PP 人群 临床有效率 :试验组 92. 5 % ,对照组 71. 4 % 。经统计学检验试验组有效率优于对照组。细 菌学清除率试验组 100 % ,对照组为 93. 3 % ,差异无显著性。两组均未发现严重的药物不良反应。结论 　莫西沙星治疗 皮肤感染的疗效较好 ,无严重不良反应事件出现。 [ 关键词] 　莫西沙星 ;左旋氧氟沙星 ;疗效 ;安全性 ;临床实验 ( ) [ 中图分类号] 　R 751. 05 　　　[文献标识码] 　A 　　　[文章编号] 　1001 - 7089 2002 06 - 0379 - 03 A Randomized ,DoubleBlind ,Compared Study of Moxifloxacin for Treatment of Skin Infection CAO Yuchun ,CHEN Xingping ,XU Zusen Depart ment of Derm atology , Tongji Hospital , Tongji Medical College , Huaz hong U niversity of Science and Technology , W uhan 430030 , China Abstract : 　Objective 　To evaluate the efficacy and safety of moxifloxacin in the treatment of patients with acute uncompli cated skin infection. Methods 　A randomized doubleblind compared study was used to compare the efficacy and safety of moxi floxacin 400mg tablets ,orally ,once daily to levofloxacin 200mg tablets ,orally ,twice daily in the treatment of patients with acute uncomplicated skin infection. Results 　In the PP population ,1 day posttreatment efficacy rates were 95. 5 % for moxifloxacin vs. 71. 4 % for levofloxacin ,the efficacy rate of moxifloxacin was statistically better than that of levofloxacin and the rates of bacterio logical eradication were 100. 0 % for moxifloxacin vs. 93. 3 % for levofloxacin ,and the difference of bacteriological eradication rates in two groups was no statistically significant. There were no serious adverse drug reactions in cl