手足口病普通和重症病例临床特征及病原学研究.docVIP

精品论文 参考文献 手足口病普通和重症病例临床特征及病原学研究 彭达意 　　（广东省深圳市坪山新区人民医院 518118） 　　【摘要】 目的：针对普通和重症手足口病患儿的临床研究以及病原学研究。方法：选取我院于2014年6月至12月期间收治的260例手足口病患儿做以回顾性分析，检测其临床特征和病原学。结果：普通病例与重症病例在口腔溃疡、皮疹稀少、消化系统症状、神经系统症状以及心血管系统症状几方面差异具有统计学意义（Plt;0.05），在手足皮疹、呼吸系统症状两方面差异不具有统计学意义（Pgt;0.05）。病原学研究中，EV71检出率、EV71+EV、CA16+EV的感染率方面重症病例与普通病例间具有统计学意义（Plt;0.05），在病毒分离和PCR检测、CA16、EV方面重症病例与普通病例间不具有统计学意义（Pgt;0.05）。结论：手足口病普通和重症的患儿在临床上具有明显差异，二者的病原学也有不同。 　　【关键词】手足口病；病原学；临床研究 　　【中图分类号】R725.1 【文献标识码】A 【文章编号】2095-1752（2015）07-0033-02 　　Hand, foot and mouth disease is common and severe cases clinical features and etiology study Peng Dayi. Pingshan District Peoples Hospital of Shenzhen City, Guangdong Province, Shenzhen 518118, China 【Abstract】 Objective In view of the common and severe hand, foot and mouth disease with clinical research and etiology study. Methods Select our hospital from June 2014 to December 260 cases admitted during the period of children with hand, foot and mouth disease do with retrospective analysis, detection of its clinical features and etiology. Results Ordinary rare case and severe cases in the oral cavity ulcer, skin rashes, symptoms of digestive system, nervous system and cardiovascular system symptoms a few differences statistically significant (P lt; 0.05). Etiology study, the detection rate, + EV EV71 and CA16 + EV EV71 infection rates of severe cases with normal cases between statistically significant (P lt; 0.05), the separation and PCR detection, virus CA16, EV between severe cases with normal cases have no statistical significance (P gt; 0.05). Conclusions Children with hand, foot and mouth disease common and severe in clinic has obvious differences, the etiology of both are also different. 　　【Key words】Hand, foot and mouth disease; Etiology; Clinical research 　　手足口病是一种多发于儿童的常见疾病，由肠道病毒引起，在手、足、口等处出现皮疹，一些患儿还有可能出现脑炎、心肌炎等并发症，甚至造成死亡。引起手足口病的主要病原主要是EV，其属于RNA类病毒，包括多种病毒类型[1]。如今手足口病发病率逐年上升，需要对其临床特征及病原学进行研究，找出有效治疗方式，帮助患儿恢复正常生活。 　　1.资料与方法 　　1.1 一般资料 　　选取我