阿司匹林与硫酸氢氯吡格雷联合治疗脑梗死的疗效及安全性.docVIP

阿司匹林与硫酸氢氯吡格雷联合治疗脑梗死的疗效及安全性 张佳琦 刘洋 唐淑洁 赵旭伟 张唯聪 齐齐哈尔医学院附属第一医院药剂科 齐齐哈尔医学院附属第一医院神经科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的:探讨阿司匹林与硫酸氢氯吡格雷联合治疗脑梗死的临床疗效和安全性。方法:选取2015年7月—2017年2月齐齐哈尔医学院附属第一医院收治的脑梗死患者92例, 采用双盲、随机数字表法分为对照组和观察组, 每组46例。在常规治疗基础上, 对照组患者单独使用阿司匹林治疗, 观察组患者使用阿司匹林与硫酸氢氯吡格雷联合治疗, 观察两组患者的临床疗效、神经功能缺损评分及不良反应发生情况。结果:观察组患者总有效率为95.65% (44/46) , 明显高于对照组的69.57% (32/46) ;治疗后, 观察组患者平均神经功能缺损评分为 (8.9±4.1) 分, 明显低于对照组的 (13.5±5.8) 分;观察组患者不良反应发生率为10.87% (5/46) , 明显低于对照组的34.78% (16/46) , 以上差异均有统计学意义 (P0.05) 。结论:与单用阿司匹林相比, 阿司匹林与硫酸氢氯吡格雷联合治疗脑梗死的疗效更佳, 且具有较高的安全性。 关键词： 阿司匹林; 硫酸氢氯吡格雷; 脑梗死; 安全性; 作者简介：张佳琦 药师。研究方向:临床药学。E-mail:274734415@ 收稿日期：2017-07-10 Efficacy and Safety of Aspirin Combined with Clopidogrel Bisulfate in Treatment of Cerebral Infarction ZHANG Jiaqi LIU Yang TANG Shujie ZHAO Xuwei ZHANG Weicong Dept. of Pharmacy, the First Affiliated Hospital of Qiqihar Medical University; Dept. of Neurology, the First Affiliated Hospital of Qiqihar Medical University; Abstract： OBJECTIVE: To probe into the efficacy and safety of aspirin combined with clopidogrel bisulfate in treatment of cerebral infarction. METHODS: 92 patients with cerebral infarction admitted into the First Affiliated Hospital of Qiqihar Medical University from Jul. 2015 to Feb. 2017 were selected to be divided into the control group and the observation group via the double-blind and random number table, with 46 cases in each. Based on the conventional treatment, the control group received aspirin alone, while the observation group was given aspirin combined with clopidogrel bisulfate. The clinical efficacy, neurologic impairment score and incidence of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of observation group was 95. 65% ( 44/46) , significantly higher than that of control group 69. 57% ( 32/46) ; after treatment, the average nerve function defect score of observation group was ( 8. 9 ± 4. 1) scores, significantly lower than