我国一些影响睡眠的营养素食品及药食两用植物研究-中国卒中杂志.PDF

※专题论述 食品科学 2015, Vol.36, No.11 261 我国一些影响睡眠的营养素、食品及药食 两用植物研究进展 应 剑，孟庆佳，衣 喆，王春玲* （中粮营养健康研究院营养与代谢中心，北京 102209 ） 摘  要：良好的睡眠对于维持人体的生理健康及精神健康至关重要。目前用于治疗失眠的镇静催眠药普遍存在一定 的安全隐患，对其应用造成了限制。一些食品及药食两用植物中的活性成分可以作用于人体中枢神经系统，改善睡 眠质量，且服用方式符合人们的日常饮食习惯，安全性高，是改善轻度睡眠障碍的有效替代方法。本文从睡眠的神 经生物学机制出发，从临床及临床前研究证据、活性成分及作用机制等角度对符合我国法规规定的食品、营养素、 药食同源植物和食品添加剂的镇静催眠活性进行分析，为我国食品工业界研发具有改善轻度睡眠障碍的功能性食品 提供科学参考依据。 关键词：食品；睡眠；镇静催眠；营养素；药用植物；神经递质；临床前；临床 Advances in Research of Sedative and Hypnotic Effects of Nutrients, Foods and Medical Plants in China * YING Jian, MENG Qingjia, YI Zhe, WANG Chunling (Nutrition and Metabolism Center, COFCO Nutrition and Health Research Institute, Beijing 102209, China) Abstract: ’ Sleep rhythm is regulated by the central nervous system. A good night s sleep is essential for maintaining physical and mental health. Hypnotic drugs can improve the quality of sleep; however, because of possible safety problems, their applications are restricted. Alternative methods are required, especially for treating mild somnipathy. Some foods and medicinal plants used in the daily diet can regulate the central nervous system and improve sleep quality. Thus, functional foods can be a safe alternative method to apply in somnipathy. In this review, in order to provide scientific evidence for the food industry to develop functional foods for reducing sleep disturbance, food and food additives which meet the requirements of laws and regulations in China are investigated. This paper starts with a review of the neurobiological mechanisms o