木香及其炮制品的抗腹泻作用与机制研究.docVIP

精品论文 参考文献 木香及其炮制品的抗腹泻作用与机制研究 辽宁中医药大学药学院，辽宁 大连 116600 基金项目：辽宁省自然基金项目（201202153），辽宁省教育厅一般项目（L2012350），教育部新教师博士点基金项目（20122133120006） 作者简介：张旭（1978—），女，副教授， 博士，硕士导师，研究方向为中药炮制工艺与原理解析。 [摘要] 目的 研究木香及其炮制品对实验动物腹泻的影响，探讨其抗腹泻作用机制。方法 以蓖麻油和番泻叶造成小鼠腹泻，ig木香生品和炮制品水煎液，测定小鼠腹泻指数，比较木香及其炮制品的抗腹泻作用；测定正常大鼠血清内D-木糖含量和胃液胃蛋白酶活力，探讨抗腹泻作用机制。结果 对番泻叶致泻的小鼠止泻作用强弱顺序为麸煨品＞纸煨品＞生品，对蓖麻油致泻的小鼠止泻作用强弱顺序为麸煨品＞生品＞纸煨品。对番泻叶致泻的小鼠，木香生品组的止泻作用随着浓度的增加而减弱，麸煨品的止泻作用随着浓度的增加而增强。麸煨木香低剂量可明显提高大鼠血清内D-木糖含量，保持胃蛋白酶活力。结论 麸煨木香长于治疗小鼠大肠性腹泻，在临床应用上可替代纸煨品，其作用机制可能与其有效地促进小肠吸收，保持胃蛋白酶活力，从而达到实肠止泻的目的有关。 [关键词]： 木香;麸煨品;腹泻指数;D-木糖;胃蛋白酶 【中图分类号】R458.7【文献标识码】A【文章编号】1001-5213(2016)08-0006-03 Research on the Anti-Diarrhea Effect and the Mechanism of the Raw and Processed Aucklandiae Radix ZHANG Xu 1, HOU Ying, FAN Bing-bing, JIA Tian-zhu （pharmacuetical school,Liaoning University of Traditional Chinese Medicine ,Liaoning Dalian 116600） [Abstract]：Objective To observe the anti-diarrhea effect and mechanism of Aucklandiae Radix and its processed products in experimental animal. Method Establish the senna and the castor oil induced diarrhea model，the decoctions of the raw and the processed Aucklandiae Radix were given by intragastic admistration, and then estimate the diarrhea index in mice. To explore the anti-diarrhea mechanism by estimating the D-xylose serum level and the pepsin activity of gastric acid in normal rats. Result The diarrhea index results show that the Anti-diarrhea effect of the bran-roasted material is stronger than that of the paper-roasted product and the raw material. Comparing with the anti-diarrhea effect of the different dose materials on senna induced diarrhea mice, the effect of the raw product decreases with the increasing concentration, while the effect of bran-roasted product is opposite. The low dose of bran-roasted Aucklandiae Radix can raise the D-xylose serum level and maintain the pepsin activity in rats significantly. Conclusion The bran-roasted Aucklandiae Radix is good at large intestinal diarrhea of mice and c