氯吡格雷治疗以TIA为表现的急性脑梗死患者的疗效观察.docVIP

精品论文 参考文献 氯吡格雷治疗以TIA为表现的急性脑梗死患者的疗效观察 佳木斯市中心医院 154000 【摘 要】目的：对负荷量和常规量氯吡格雷早期治疗以TIA为临床表现的急性脑梗死患者的疗效对比观察。方法：选择2010年—2014年本院以TIA为临床表现的急性脑梗死收住院患者65例作试验组；随机选择2008年—2010年的相似病例 61例作对照组，比较氯吡格雷负荷量【300mg 日一次（Qd）口服】与常规量【75mg Qd口服】对以TIA为临床表现的急性脑梗死疗效。结果：从发作情况分析，试验组有效率92.3%，对照组有效率82.0%，有统计学意义（Plt;0.05）。对平均发作次数及平均发作时长予以统计学分析，有临床意义。从NIHHS评分看，试验组由发病时13.31plusmn;1.56下降至14d时2.91plusmn;0.12，对照组由发病时13.06plusmn;2.05下降至14d 3.75plusmn;1.81。出血风险实验组0.03%，对照组0.02%，无统计学差异。结论：负荷量氯吡格雷治疗以TIA为临床表现的急性脑梗死疗效确有明显提高，而出血风险并无统计学差异，对在基层医院由于各种原因不能进行溶栓治疗的患者值得尝试。 【关键词】氯吡格雷；负荷量；短暂脑缺血发作；急性脑梗死 Abstract：Objective：to early load and conventional dose clopidogrel in the treatment ofTIA for comparative observation on curative effect of acute cerebral infarction in patients with clinical manifestations.Methods：from 2010 to 2014 in our hospital with TIAfor acute cerebral infarction clinical manifestations of hospitalized patients in 65 cases of experimental group were randomly selected from 2008 to 2010；the similarity of 61 cases as control group，compared with clopidogrel[300mg once a day（Qd）]and 75mg[oral routine dose of oral Qd]in patients with acute cerebral infarction effect of TIA in clinical manifestations.Results：from the analysis of the attack，the effective rate in experimental group was 92.3%，the effective rate of control group was 82%，there was statistical significance（Plt;0.05）.Statistical analysis of the frequency of seizures and thelength of the average onset，clinical significance.Look at the score from NIHHS，the experimental group by the onset age of 13.31 + 1.56 2.91 + 0.12 drops to 14d，the control group by the onset of 13.06 + 2.05 3.75 + 1.81 dropped to 14D.The risk of hemorrhage in experimental group 0.03%，0.02% in the control group，no significant difference.Conclusion：the loading dose of clopidogrel in the treatment of TIA is effective for acute cerebral infarction clinical manifestations were obviously increased，but there was no statistical difference in the risk of bleeding in the primary hospit