浅析抗乙肝高效免疫球蛋白联合乙肝疫苗对乙肝母婴垂直传播的预防.docVIP

精品论文 参考文献 浅析抗乙肝高效免疫球蛋白联合乙肝疫苗对乙肝母婴垂直传播的预防 绥化市第一医院 152000 【摘 要】目的 研究分析抗乙肝高效免疫球蛋白（HBIG）联合乙肝疫苗（HBVac）对乙肝母婴垂直传播的预防效果。方法 此次研究的对象是选择80例HBsAg阳性孕妇。将其临床资料进行回顾性分析，并按照抽签方法随机地均分为对照组与观察组，每组均为40例。观察组自孕28w开始注射HBIG联合HBVac进行治疗，对照组未进行免疫注射治疗。比较两组新生儿HBsAg阳性率、HBV-DNA阳性率、抗-HBs阳性率以及治疗过程中不良反应发生情况。结果 对照组HBsAg阳性率、HBV-DNA阳性率、抗-HBs阳性率分别为10.00%、27.50%及57.50%，观察组HBsAg阳性率、HBV-DNA阳性率、抗-HBs阳性率分别为2.50%、2.50%及85.00%，两组上述各指标差异均具有统计学意义（Plt;0.05）；两组治疗过程中均未见任何不良反应的发生。结论 抗乙肝高效免疫球蛋白（HBIG）联合乙肝疫苗（HBVac）能够有效地预防乙肝母婴垂直传播，且安全性较高，应加以推广及应用。 　　【关键词】抗乙肝高效免疫球蛋白；乙肝疫苗；慢性乙肝；垂直传播 　　Abstract：Objective To study the effect of hepatitis B immunoglobulin （HBIG） combined with hepatitis B vaccine （HBVac） on the prevention of hepatitis B virus vertical transmission. Methods the study subjects were selected 80 cases of HBsAg positive pregnant women. The clinical data were retrospectively analyzed，and randomly divided into control group and observation group，each group had 40 cases. The observation group was treated with HBIG combined with HBVac，and the control group did not have the immune injection treatment. The positive rate of HBsAg，the positive rate of HBV-DNA，the positive rate of anti -HBs，and the incidence of adverse reactions in the treatment of the two groups were compared. Results the positive rate of the control group，the positive rate of HBsAg，HBV-DNA and anti -HBs were 10%，27.50% and 57.50%，to observe the positive rate of HBsAg group，the positive rates of HBV-DNA and anti -HBs were 2.50%，2.50% and 85%，the difference between the two groups were statistically significant （Plt; 0.05） occurred in two groups；in the process there was no any adverse reaction. Conclusion anti hepatitis B immunoglobulin （HBIG） combined with hepatitis B vaccine （HBVac） can effectively prevent mother to child transmission of hepatitis B，and the safety is higher，should be popularized and applied. Key words：anti hepatitis B immunoglobulin；hepatitis B vaccine；chronic hepatitis B；vertical transmission 我国属于乙型肝炎高发地区，慢性乙肝感染患者约为30%～50%的是